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Prävention von arteriellen Embolien

Indikation
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Nebenwirkungen
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Cimetidin (#R: -1; #F: 1)
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Vertreter
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Indikation
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Indikation
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Nebenwirkungen
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Hemmung der Natrium/Kalium-ATPase in den Kardiomyozyten
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- negativ dromotrop
- geringe therapeutische Breite

Indikationen
- Tachykardes Vorhofflimmern
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- Paroxysmale supraventrikuläre Tachykardie

Nebenwirkungen
- Gastrointestinale Nebenwirkungen
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Kontraindikationen
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= Thrombozytenaggregationshemmer
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- Antiallergikum
- Juckreiz
- Antiemetikum (1. Generation)
- Schlafmittel (1. Generation)

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-> Diphenhydramin
-> Meclozin
-> Promethazin
-> Clemastin

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- Kaum sedierend
-> Loratadin
-> Cetirizin
-> Azelastin
-> Fexofenadin

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- Antiallergikum
- Juckreiz
- Antiemetikum (1. Generation)
- Schlafmittel (1. Generation)

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-> Cetirizin
-> Azelastin
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-> Dimetinden
-> Diphenhydramin
-> Meclozin
-> Promethazin
-> Clemastin

2) 2. Generation
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-> Loratadin
-> Cetirizin
-> Azelastin
-> Fexofenadin

Indikationen
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- Antiallergikum
- Juckreiz
- Antiemetikum (1. Generation)
- Schlafmittel (1. Generation)

Kontraindikationen (1. Generation - Anticholinerg)
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- Pylorusstenose
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Kompetitiver Antagonismus am Histamin H1-Rezeptor

Vertreter
1) 1. Generation
- ZNS-gängig
- Ausgeprägt sedierend
- Anticholinerge Nebenwirkungen
-> Dimetinden
-> Diphenhydramin
-> Meclozin
-> Promethazin
-> Clemastin

2) 2. Generation
- Kaum sedierend
-> Loratadin
-> Cetirizin
-> Azelastin
-> Fexofenadin

Indikationen
- Anaphylaktischer Schock
- Antiallergikum
- Juckreiz
- Antiemetikum (1. Generation)
- Schlafmittel (1. Generation)

Kontraindikationen (1. Generation - Anticholinerg)
- Prostatahyperplasie mit Bildung von Restharn
- Winkelblockglaukom
- Pylorusstenose
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Glukokortikoide (#R: 0; #F: 0)
Antiinflammatorische (Akut) und immunsuppressive Wirkung (Langfristig)
- Gabe möglichst einmalig morgens vor 8 Uhr
- NICHT i.m.!

Vertreter
1) Cortisol (Hydrocortison)
- Cushing-Schwelle: 30mg
- relative glukokortikoide Wirkung: 1
- relative mineralkortikoide Wirkung: 1
2) Prednisolon
- Cushing-Schwelle: 7,5mg
- relative glukokortikoide Wirkung: 4
- relative mineralkortikoide Wirkung: 0,8
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- Cushing-Schwelle: 1mg
- relative glukokortikoide Wirkung: 30
- relative mineralkortikoide Wirkung: -
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- Morbus Addison
- Adrenogenitales Syndrom
- Allergische Reaktionen und anaphylaktischer Schock
- Antiemetisch
- Akuter Asthma-Anfall
- Lungenödem / Hirnödem
- multipler Sklerose
- Morbus Crohn, Sarkoidose, Sjögren-Syndrom, Morbus Basedow
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- Hypertonie, Ödeme
- Hypokalzämie -> Osteoporose
- Myopathie und Muskelatrophie
- Diabetogene Wirkung
- Menstruationsstörungen, Hirsutismus, Impotenz
- Lymphozytopenie, Eosinopenie und Monozytopenie -> Immunsuppresion
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- Granulozyten↑ → dadurch insgesamt Leukozytose
- Kombination aus Glukokortikoiden und NSAR erhöht das Ulkusrisiko (x10)
- Katarakt
- Glaukom
- Euphorie oder Dysphorie
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Antiinflammatorische (Akut) und immunsuppressive Wirkung (Langfristig)
- Gabe möglichst einmalig morgens vor 8 Uhr
- NICHT i.m.!

Vertreter
1) Cortisol (Hydrocortison)
- Cushing-Schwelle: 30mg
- relative glukokortikoide Wirkung: 1
- relative mineralkortikoide Wirkung: 1
2) Prednisolon
- Cushing-Schwelle: 7,5mg
- relative glukokortikoide Wirkung: 4
- relative mineralkortikoide Wirkung: 0,8
3) Dexamethason
- Cushing-Schwelle: 1mg
- relative glukokortikoide Wirkung: 30
- relative mineralkortikoide Wirkung: -
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Indikationen
- Morbus Addison
- Adrenogenitales Syndrom
- Allergische Reaktionen und anaphylaktischer Schock
- Antiemetisch
- Akuter Asthma-Anfall
- Lungenödem / Hirnödem
- multipler Sklerose
- Morbus Crohn, Sarkoidose, Sjögren-Syndrom, Morbus Basedow
- Induktion der fetalen Lungenreife

Nebenwirkungen
- Hypokaliämie
- Hypertonie, Ödeme
- Hypokalzämie -> Osteoporose
- Myopathie und Muskelatrophie
- Diabetogene Wirkung
- Menstruationsstörungen, Hirsutismus, Impotenz
- Lymphozytopenie, Eosinopenie und Monozytopenie -> Immunsuppresion
- Thrombozyten↑ → erhöhtes Thromboserisiko
- Granulozyten↑ → dadurch insgesamt Leukozytose
- Kombination aus Glukokortikoiden und NSAR erhöht das Ulkusrisiko (x10)
- Katarakt
- Glaukom
- Euphorie oder Dysphorie
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Indikationen
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Therapie
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Therapie
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Indikationen
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Indikationen
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Antiemetika in der Schwangerschaft (#R: 0; #F: 0)
1) Antihistaminika (H1-Blocker)
- Meclozin
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Candesartan (#R: 0; #F: 0)
= Sartan

Indikationen
- Diabetes mellitus (Mittel der 1. Wahl: Nephroprotektiv)
- Herzinsuffizienz
- Zustand nach Herzinfarkt
- Junge Patienten
- Metabolisches Syndrom

Nebenwirkungen
- Hypotension
- Hyperkaliämie (+ Thiazide gleicht aus)
- Angioneurotisches Ödem
- Allergische Reaktionen
- Schwindel
- Kopfschmerzen

Kontraindikationen
- Beidseitige Nierenarterienstenose
- Hyperkaliämie
- Schwangerschaft und Stillzeit
Thyreostatika in der Schwangerschaft (#R: 0; #F: 0)
1) Propylthiouracil: Insb. im 1. Trimenon
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Losartan (#R: 0; #F: 0)
= Sartan

Indikationen
- Diabetes mellitus (Mittel der 1. Wahl: Nephroprotektiv)
- Herzinsuffizienz
- Zustand nach Herzinfarkt
- Junge Patienten
- Metabolisches Syndrom

Nebenwirkungen
- Hypotension
- Hyperkaliämie (+ Thiazide gleicht aus)
- Angioneurotisches Ödem
- Allergische Reaktionen
- Schwindel
- Kopfschmerzen

Kontraindikationen
- Beidseitige Nierenarterienstenose
- Hyperkaliämie
- Schwangerschaft und Stillzeit
Antidiabetika in der Schwangerschaft (#R: 0; #F: 0)
1) Insulin

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Aliskiren (#R: 0; #F: 0)
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Indikation
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Nebenwirkungen
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