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Kompetitive Hemmung der HMG-CoA-Reduktase
- Abendliche Einnahme (v.a. bei Simvastatin)
- Kombinationstherapie mit Colestyramin

Vertreter
1) Simvastatin
- HWZ: 2h
- CYP3A4
2) Pravastatin
- HWZ: 2h
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3) Lovastatin
- HWZ: 3h
- CYP3A4

4) Atorvastatin
- HWZ: 14h
- CYP3A4

Indikation
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Nebenwirkungen
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Interaktionen
Erhöhte Myopathie- und Rhabdomyolyseneigung bei:
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- Nikotinsäure
- Makrolide (Erythromycin)

Kontraindikationen
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- Schwangerschaft, Stillzeit
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Aktivierung des PPARα-Rezeptors
- LDL 10-20%↓
- HDL 5-20%↑
- Triglyceride 20-40%↓

Vertreter
1) Bezafibrat
2) Fenofibrat
3) Gemfibrozil

Indikation
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Nebenwirkungen
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- Myalgie
- vermehrte Cholelithiasis

Kontraindikation
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Austauscherharz (Bindung der Gallensäure im Darm)
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Vertreter
1) Cholestyramin
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Indikation
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- Pruritus auf dem Boden erhöhter Gallensäurewerte (Cholestase)
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- Brennen
- Pruritus
- Durchfall, Flatulenz, Bauchschmerzen
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- Hyperurikämie
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Kontraindikationen
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- Gicht
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Indikation
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Vertreter
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Vertreter
- Mannit
- Glycerin
- Sorbit

Indikation
- Hirnödem
- akutes Glaukom

Nebenwirkungen
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Kontraindikation
- kardiale Dekompensation
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- Ausscheidung von Kalium↑
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- Hypokaliämie oder Hyponatriämie
- Hyperkalzämie
- Exsikkose

Interaktionen
- Verstärkte Digitalis-Wirkung (Hypokaliämie)
- Verstärkung der Lithium-Wirkung
- Wirkungsabschwächung von Zytostatika und depolarisierender Muskelrelaxanzien
- Abgeschwächte antihypertensiven Wirkung durch NSAR
Schleifendiuretika (#R: 0; #F: 0)
Blockade des Na+-K+-2Cl--Kotransporters
- Venodilatation bei intravenöser Applikation → Vorlastsenkung
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Vertreter
1) Furosemid

Indikationen
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Vertreter
1) Eplerenon
2) Spironolacton
- ♂: Gynäkomastie, Impotenz
- ♀: Amenorrhoe, Hirsutismus

Indikationen
- Primärer Hyperaldosteronismus
- Herzinsuffizienz (Ab Stadium II indiziert, Verbesserung der Prognose)
- Leberzirrhose mit Aszites bzw. Ödemen

Nebenwirkungen
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Pharmakodynamik (#R: 0; #F: 0)
beschreibt, wie das Medikament an seinem Zielort in Abhängigkeit der Dosis und anderer Faktoren wirkt!

1) Wirkung an Rezeptoren
2) Wirkung an Enzymen
3) Wirkung an DNA
4) Wirkung durch physikalischen/chemischen Einfluss
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1) Statine
- alle außer Pravastatin
2) Steroidhormone
- Östrogene
- Glukokortikoide
- Testosteron
3) Orale Kontrazeptiva
4) Makrolide
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5) Carbamazepin
6) Benzodiazepine
7) HIV-Virostatika
8) Kalziumantagonisten
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9) Amiodaron
10) Antimykotika
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Zahlreiche weitere Medikamente
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- Donepezil
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Indikation
- Myasthenia gravis (Pyridostigmin)
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- Leichte und mittelschwere Demenzen

NW
- Bradykardie und Herzrhythmusstörungen
- Diarrhoe
- Schweißausbrüche
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- Übelkeit
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Direkte Parasympathomimetika (#R: 0; #F: 0)
1) Pilocarpin
2) Carbachol

Indikation
- Glaukom

NW
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Parasympatholytika (#R: 0; #F: 0)
= Anticholinergika
Kompetitive Hemmung am M-Cholinorezeptor.

Vertreter
1) Liquorgängig
- Atropin (bei Bradykardien während der OP-Einleitung)
- Scopolamin (bei Kinetosen)
- Tropicamid (diagnostischen Mydriasis)
- Biperiden (M. Parkinson; Antidot bei typischen Antipsychotika)
- Oxybutynin, Darifenacin (bei imperativem Harndrang)

2) Nicht Liquorgängig
- Butylscopolamin (Spasmolyse - Pankreatitis / akuter Choledocholithiasis)
- Ipratropiumbromid (Asthma + COPD)

Wirkung
- Mydriasis
- Akkommodationslähmung
- Verengung des Kammerwinkels
- Bronchodilatation
- Abnahme der bronchialen Sekretion
- Zunahme der Herzfrequenz
- Verkürzung der AV-Überleitung
- Abnahme der Peristaltik
- Verminderte Sekretion
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Ätiologie
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- Trizyklische Antidepressiva: Doxepin, Amitriptylin, Imipramin und Trimipramin
- Parasympatholytika
- Antipsychotika
- Antihistaminika der 1. Generation

Symptome
- Mundtrockenheit
- heiße Haut
- Tachykardie, Herzrhythmusstörungen
- Mydriasis
- zentrale Erregung

Therapie
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β-2-Sympathomimetika (#R: 0; #F: 0)
Stimulation des β2-Rezeptors, gering auf β1 (Nebenwirkungen!)

Vertreter
1) Kurzwirksam (Asthma ab Stufe I)
- Salbutamol
- Fenoterol (Tokolyse - Geburtshilfe)
- Reproterol
- Terbutalin

2) Langwirksam (Asthma ab Stufe III)
- Formoterol
- Salmeterol

Wirkung
- Bronchodilatation
- Tokolyse
- Dilatation der Gefäße
- Hemmung der Histaminfreisetzung

NW
- Hyperglykämie
- Hypokaliämie
- Tachykardie, Unruhe, Tremor

Kontraindikationen
- Phäochromozytom
- Glaukom
- Ausgeprägte Hyperthyreose
- Hypertrophe obstruktive Kardiomyopathie
Rezeptoren (#R: 0; #F: 0)
Auge - α1
- Mydriasis
- Fernakkommodation

Bronchien - β2
- Bronchodilatation

Herz - β1
- Herzfrequenz↑
- Kontraktilität↑
- Überleitung↑

Gefäße - α1
- Kontraktion von renalen und dermalen Gefäßen (führend)
Gefäße - β2
- Periphere Gefäßdilatation

Magen-Darm-Trakt - α1
- Sphinkterkontraktion
- Sekretion↓
Magen-Darm-Trakt - β2
- Peristaltik↓

Harnblase - α1
- Sphinkterkontraktion
Harnblase - β2
- Detrusorerschlaffung

Skelettmuskulatur - β2
- Kontraktion↑
- Glykogenolyse↑

Fettgewebe - β1
- Lipolyse↑
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- Zentrale Drosselung der Aktivität der sympathischen Nervenfasern
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Verterter
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- NW: Depression

2) Urapidil
- Postsynaptische Blockade des α1-Rezeptors
- Stimulierung zentraler Serotoninrezeptoren
-> bei hypertensiver Krise
- NW: Kopfschmerzen und gastrointestinale Nebenwirkungen

3) α-Methyl-Dopa
- falscher Neurotransmitter (α-Methylnoradrenalin)
- Chronische Hypertonie in der Schwangerschaft
- NW: Na+- und H20-Retention

4) Clonidin
- Stimulation zentraler prä- und postsynaptischer α2-Rezeptoren
- Alkoholentzugstherapie + Glaukom + Hypertensive Krisen
- NW: Initialer Blutdruckanstieg; Rebound-Hypertonie nach Absetzen

5) Moxonidin
- Stimulation zentraler Imidazolin-Rezeptoren
- Arterielle Hypertonie

6) Tizanidin
- Stimulation zentraler α2-Rezeptoren
- zentrales Spasmolytikum

NW
- orthostatische Dysregulation
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