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Statistische Auswertung
ZURÜCK
Morbus Weil (#R: 6; #F: 9)
Spätphase einer Leptospirose

Systemischer Verlauf mit Organbefall
- Leber: Hepatitis mit Transaminasenerhöhung und Ikterus
- Nieren: Nephritis und akutes Nierenversagen
- ZNS: Lymphozytäre Meningoenzephalitis
Melkersson-Rosenthal-Syndrom (#R: 8; #F: 6)
granulomatöse Erkrankung

Symptomtrias
- Lingua plicata (Faltenzunge)
- Cheilitis granulomatosa (Ober- oder Unterlippenschwellung)
- rezidivierende periphere Fazialislähmung.
Caplan-Syndrom (#R: 10; #F: 5)
Silikose + rheumatoider Arthritis
Cowden-Syndrom (#R: 9; #F: 5)
• Papeln und Hyperkeratosen der Haut und Schleimhäute
• Multiple gastrointestinale Polypen und Adenome
• Veränderungen im Bereich der Schild- und Brustdrüse
• Erhöhtes Risiko an einem kolorektalen Karzinom zu erkranken
• Autosomal-dominant vererbt
Muir-Torre-Syndrom (#R: 6; #F: 5)
Veranlagung zu bestimmten Hauttumoren meistens bei MSH2-Mutation
Talgdrüsenadenome
Keratoakanthome
Chorea (#R: -4; #F: 5)
Extra-pyramidal-motorische Erkrankungen
- hyperkinetisches Syndrom
- psychische Auffälligkeiten
- Spätfolge: Demenz

Chorea major Huntington
- Häufigkeitsgipfel um das 40. Lebensjahr
- Autosomal-dominante Trinukleotid-Repeat-Vergrößerung (CAG-Repeat)
- irreversibler Untergang von GABA-ergen Neuronen im Striatum durch Ablagerungen von Huntingtin

Chorea minor Sydenham
- 6-13 Jahre
- häufig Mädchen
- im Rahmen eines rheumatischen Fiebers (ß-hämolysierenden Streptokokken der Gruppe A)
- Ablagerung von Immunkomplexe im Striatum

Symptome bei Chorea major
- Plötzlich einschießende Hyperkinesien(Grimassieren, Chamäleonzunge und Klavierspielerbewegungen)
- Dysarthrophonie und ruckartige Hyperlordosierung
- Vegetative Symptome (Hyperhidrosis, Harninkontinenz)
- Mutismus
- Blepharospasmus
- Kachexie
- demenzielle Entwicklung

Therapie Corea major
- Riluzol gegen Glutamatausschüttung
- Tiaprid oder Sulpirid gegen Hyperkinesien
- Atypische Neuroleptika bei psychotischen Zuständen
- SSRI bei depressiven Zuständen

Prognose
- Chorea major: schlecht
- chorea minor: gut
Mikulicz-Syndrom (#R: 5; #F: 4)
Schwellung der Tränen- und Mundspeicheldrüse

- Schmerzlos
- Paraneoplastisch
Thallium (#R: -1; #F: 4)
Klinik
- Helle Quersteifen an Fuß-/Fingernägeln (Mees-Streifen)
- Haarausfall
- Polyneuropathie ("burning feet")
- Gedächtnisstörungen

Diagnostik
- Nachweis im Urin oder Blut
Pierre-Marie-Bamberger-Syndrom (#R: 7; #F: 3)
Hypertrophe pulmonale Osteoarthropathie
• Meist Folge der chronischen Hypoxie (→ bei allen chronischen Lungenerkrankungen möglich )
• Schwellung und Schmerzen von Diaphysen der Extremitäten
• Uhrglasnägel und Trommelschlegelfinger
Dubin-Johnson-Sprinz-Syndrom (#R: 7; #F: 3)
Störung der Bilirubinausscheidung der Leber

- Fehlfunktion des MRP-2-Transporters.
- Autosomal rezessiv
Shy-Drager-Syndrom (#R: 6; #F: 3)
Multisystematrophie (MSA)
- vorrangig parkinsonoider Symptomatik (MSA-P)
- Dysarthrie
- Tremor.
Klüver-Bucy-Syndrom (#R: 8; #F: 3)
Bei z.n. bilateraler Temporallappenschädigung
- Affektion des limbischen Systems
- Starke orale Tendenzen (alles wird in den Mund genommen)
- Angstverlust
- Hypersexualität

Ätiologie
- Enzephalitiden
- chronische Degeneration
- Traumen
Spastische Spinalparalyse (#R: -1; #F: 3)
nicht-entzündliche, neurodegenerative Erkrankung
- Untergang der Pyramidenbahn und des Gyrus praecentralis.
- autosomal dominant vererbt

Symptome
- spastischen Paresen
- Hohlfußbildung
- Dysarthrie
- Harnblaseninkontinenz
- kognitiven Störungen

Therapie
keine kausale Therapie
meist nur langsam progredient
Urgeinkontinenz - Therapie (#R: -2; #F: 3)
Anticholinergika (Spasmolytika)
- Oxybutynin
- Solifenacin
- Trospiumchlorid

Alpha-Rezeptor-Blocker
- Tamsulosin

Parasympatholytika
- Butylscopolaminbromid

Trizyklische Antidepressiva
- Imipramin (anticholinerge Wirkkomponente)

Flavoxat
adultes Still-Syndrom (#R: 3; #F: 3)
o Intermittierende hohe Fieberschübe
o Flüchtiges kleinfleckiges, makulopapulöses Exanthem
 Befällt proximale Extremitäten und Rumpf
 Auftreten häufig nur während des abendlichen Fieberschubs
o Weitere Symptome: Symmetrische Polyarthritis, Splenomegalie, Polyserositis (Pleura und Perikard)
• Labor
o Rheumafaktoren, Antinukleäre Antikörper und Anti-CCP-Antikörper: alle negativ!
Ferritin↑↑, BSG↑, CRP↑, Leukozytose
Morbus Bannwarth (#R: 5; #F: 3)
Lyme-Borreliose

- fakultativ intrazelluläre Borrelien
Polyzyklische aromatisierte Kohlenwasserstoffe (#R: 0; #F: 3)
Klinik
- Kanzerogenität v.a. an Haut und Lunge ("Schornsteinfegerkrebs")

Diagnostik
- 1-Hydroxypyren im Urin
Juvenile myoklonische Epilepsie (#R: 0; #F: 3)
= Impulsiv-Petit-mal = Janz-Syndrom

- Beginn der Erkrankung: 12.-20. Lebensjahr

- Astatischer Anfall mit plötzlichem Tonusverlust
- blitzartiges Hinfallen
- Bilateral symmetrische Myoklonien
- Wegschleudern der Extremitäten
- Meist zeitlich in der Nähe des Aufwachens
- Photosensibilität

- Immer ohne Bewusstseinsstörung

EEG:
- 3-5/s spikes and waves
- Poly-spikes-and-waves
Chondromatose (#R: 0; #F: 3)
Enchondrale Knochenneubildung als Metaplasie der Synovialis

- 30.-50. Lebensjahr
- Kniegelenk (ca. 70%)

Konventionelles Röntgen
- Röntgendichte Gelenkkörper meist gleicher Größe
Galaktogenese (#R: -2; #F: 3)
Milchsekretion

- Hohe Prolaktinspiegel
Epicondylitis humeri radialis (#R: 0; #F: 3)
funktionelle Überbeanspruchung der Sehnen von Hand- und Fingerextensoren mit nachfolgender degenerativer Veränderungen der Sehnenursprünge (Insertionstendopathie)

- Tennisellenbogen
- Schmerzen außenseitig am Ellenbogen auf
- durch Supination, Faustschluss und kräftige Dorsalextension verstärkt.
Brenneman-Syndrom (#R: 0; #F: 3)
Auftreten von diffusen Bauchschmerzen (Pseudoappendizitis) während einer Atemwegsinfektion (bspw. Tonsillitis)

- Kindesalter.
Charcot-Marie-Tooth-Krankheit (#R: -1; #F: 2)
Hereditäre motorisch-sensible Neuropathien (Typ I)

- Distal symmetrische sensomotorische Polyneuropathie
- Atrophie der Wadenmuskulatur (Storchenbeine)
M. Krabbe (#R: 4; #F: 2)
Globoidzell-Leukodystrophie (Morbus Krabbe)

- genetische Erkrankung (Mutation auf Chromosom 14)
- Zerfall der weißen Substanz des Gehirns
- fortschreitende Bewegungsstörungen
- dementielle Entwicklung
- nur wenige Kinder werden älter als einige Jahre.
Larrey-Hernie (#R: 2; #F: 2)
- Hernia diaphragmatica sternocostalis/parasternalis
- linksseitig
Kikuchi-Fujimoto-Erkrankung (#R: 7; #F: 2)
Nekrotisierende Lymphadenitis.
• Klinik: Zervikal betonte, schmerzhafte Lymphknotenschwellung mit Allgemeinsymptomatik und Fieber
Sheehan-Syndrom (#R: 4; #F: 2)
postpartaler Hypopituitarismus Ischämische Hypophysennekrose bei starkem peripartalem Blutverlust
Gorlin-Syndrom (#R: 6; #F: 2)
MEN 2b
• Medulläres Schilddrüsenkarzinom (100%)
• Phäochromozytom (ca. 50%)
• Ganglioneuromatose (fast 100%)
• Marfanoider Habitus (>95%)
Urozystitis - Antibiotika (#R: 0; #F: 2)
1. Wahl
- Nitrofurantoin
- Fosfomycin-Granulat
- Cotrimoxazol (Trimethoprim/Sulfamethoxazol)

2. Wahl
- Fluorchinolone (z.B. Ciprofloxacin)
- Cephalosporine (z.B. Cefuroxim)
- Penicilline (z.B. Amoxicillin/Clavulansäure)

Schwangerschaft
- Fosfomycin
- Cephalosporine der 2. und 3. Generation
- Pivmecillinam
Felty-Syndrom (#R: 2; #F: 2)
- schwere rheumatoide Arthritis
- seropositiv
- Splenomegalie
- Granulozytopenie

Zahlreiche weitere Symptome möglich
o Vaskulitis, die insbesondere durch Hautulzera der unteren Extremität symptomatisch wird
o Hepatomegalie
o Pleuritis, Perikarditis
o Infektionen aufgrund eines reduzierten Immunstatus
Arsen (#R: 1; #F: 2)
Klinik
- Helle Quersteifen an Fuß-/Fingernägeln (Mees-Streifen)
- Inhalation von Arsenwasserstoff → Intravasale Hämolyse mit Hämoglobinurie
- Ulzera (Nasenseptumperforation)
- Bronchialkarzinom
- Hautkrebs (Basaliom)
- Hyperkeratose
- Polyneuropathien

Diagnostik
- Nachweis im Urin

Sonstiges
- Arsenwasserstoff → Nach Knoblauch riechendes Gas

Therapie
- Magenspülung, Aktivkohle bei akuter Intoxikation
- Antidot: Dimercaptopropansulfonsäure (DMPS)
Morbus Forestier (#R: 7; #F: 2)
Diffuse idiopathische Skeletthyperostose, Spondylosis hyperostotica)
• Definition: Degenerative Erkrankung hauptsächlich der BWS und LWS
• Epidemiologie
o Keine HLA-B 27-Assoziation
o Häufig bei Diabetikern
Klinik: Bewegungseinschränkung, oftmals nicht oder nur gering schmerzhaft
Blei (#R: 1; #F: 2)
Störung der Häm-Synthese durch Inhibition der Aminolävulinsäure-Dehydratase

Klinik
- Blauschwarzer Zahnfleischsaum sowie Verfärbung der Haut
- Darmkoliken
- Anämie
- N. radialis-Lähmung
- Obstipation, Abgeschlagenheit
- Polyneuropathie
- Mentale Retardierung und Wachstumsstörungen bei Kindern
- Niere: Blei-Nephropathie

Diagnostik
- Bleibestimmung im Blut
- δ-Aminolävulinsäure und Koproporphyrin im Urin sowie in den Haaren

Sonstiges
- Basophil getüpfelte Erythroyzten

Therapie
- D-Penicillamin
- Di-Na-Ca-Ethylen-Diamin-Tetraacetat
Nickel (#R: 1; #F: 2)
Klinik
- Allergisches Kontaktekzem
- Plattenepithelkarzinom der Nase oder Nasennebenhöhle
- Bronchialkarzinom
Benzol (#R: 1; #F: 2)
Klinik
- Kopfschmerzen, Schwindel und Übelkeit
- Panzytopenie (dadurch u.a. Nasenbluten, Purpura)
- Lebensbedrohliche Arrhythmien, Bewusstlosigkeit, Atemdepression
- Akute oder chronische myeloische Leukämie
- Non-Hodgkin-Lymphome

Diagnostik
- Phenol im Urin
Chinon (#R: 1; #F: 2)
Augenschädigung
- Braunfärbung der Konjunktiva und Kornea
- Korneaerosionen
- Irregulärer Astigmatismus
Monochlorethylen - Vinylchlorid (#R: 1; #F: 2)
Bei der Herstellung von Polyvinylchlorid (PVC)

Klinik
- Schädigung von Leber, Speiseröhre und Magen
- Splenomegalie
- Thrombozytopenie
- Akroosteolysen an den Endphalangen der Finger
- Raynaud-Syndrom
- Sklerodermie-ähnliche Hautveränderungen
- Maligne Lebertumoren (insb. Hämangiosarkome)

Diagnostik
- Thiodiglykolsäure im Urin
para-tertiär-Butylphenol (#R: 1; #F: 2)
Klinik
- fleckige, Vitiligo-ähnliche Depigmentierungen der Haut
- Schädigung der Leber
- Vergrößerung der Schilddrüse (Struma)
Fragilen X-Syndrom (Martin-Bell-Syndrom) (#R: -1; #F: 2)
• Intelligenzminderung
• Körpergröße zumeist im oberen Normbereich
• Anomalien der Körperstrukturen typisch (z.B. Makrozephalus, längliches Gesicht und große Ohren)
• deutlich vergrößerte Hoden
Hyperaktivität und autistisches Verhalten
Dioxine (#R: 1; #F: 2)
Polychlorierte Dibenzodioxine und Dibenzofurane

Klinik
- Chlorakne
- Leberschädigung
- Polyneuropathie
- Knochenmarksschädigung
- teratogen
nummuläres (mikrobielles) Ekzem (#R: 2; #F: 2)
- münzförmige, 2-5cm große Herde
- an den Extremitäten

- bakterielle Ätiologie wird vermutet
M. Fabry (#R: 0; #F: 2)
lysosomale Sphingolipidose
- X-chromosomal-rezessiv
- Mangel an α-Galaktosidase A

- im Kindesalter

- akrodistale Parästhesien
- gastrointestinale Beschwerden
- Anhidrose
- Angiokeratome
- Vortexkeratopathie
Dyskeratosis follicularis (#R: 2; #F: 2)
= Morbus Darier
- autosomal-dominant vererbt

- konfluierende, rötliche Papeln
- Gesichtsmitte + Anogenitalregion + behaarten Kopf

- starker Juckreiz vor allem nach mechanischer oder thermischer Irritation
- übler Fötor.
Medikamentöse Therapieoption - Absencen (#R: 0; #F: 2)
- Valproat
- Ethosuximid
Kearns-Sayre-Syndrom (#R: 1; #F: 2)
Das Kearns-Sayre-Syndrom gehört zu den mitochondrialen Myopathien, die maternal über die Mitochondrien vererbt werden. Es geht mit Ophthalmoplegie, Retinopathia pigmentosa und Störungen des Herzreizleitungssystems einher.
Bulbospinale Muskelatrophie (#R: 0; #F: 2)
= Kennedy-Syndrom

Degeneration des 2. Motorneurons
- X-chromosomal-rezessiv
- junges Erwachsenenalter

- Infertilität
- Gynäkomastie

- Atrophie und Faszikulationen proximaler Extremitätenabschnitte (Schultergürtel), der Zungen- und Schlundmuskulatur
- Atrophien des M. temporalis
Hirntumor - WHO-Grad III (#R: 0; #F: 2)
Mittlere Überlebenszeit: 2-3 Jahre

- Astrozytom Grad III = Anaplastisches Astrozytom
- Oligodendrogliom
Litzmann-Obliquität (#R: -1; #F: 2)
Hinterer Asynklitismus
- Geburtsstillstand → Sectio caesarea
Osteoklastom (#R: 0; #F: 2)
Vom Knochenmark ausgehender Tumor mit Riesenzellen

- Häufigkeitsgipfel im 20.-30. Lebensjahr
- Epiphyse langer Röhrenknochen (meist kniegelenksnah)

Klinik
- Lokale Belastungsschmerzen
- Spontanfrakturen

Histopathologie
- Mehrkernige Riesenzellen
Tokolytika (#R: -1; #F: 2)
- Fenoterol
- - Beta-2-Sympathomimetikum
- - CAVE: Tachykardie und Blutdrucksteigerung der Mutter

- Atosiban
- - Oxytocin-Antagonist

- Magnesiumsulfat
Denny-Brown-Syndrom (#R: 0; #F: 2)
Paraneoplastische Polyneuropathie
- bei kleinzelligem Bronchialkarzinoms

- Distal-symmetrische Parästhesien
- Störungen der Propriozeption
- Störungen der vegetativen Regulation
Achylia gastrica (#R: -1; #F: 2)
Zu einer Achylia gastrica kann es z.B. im Rahmen einer Autoimmungastritis mit Atrophie des Säure-bildenden Drüsenkörpers kommen. Aufgrund des daraus resultierende Mangels an Magensäure kann aber selbst bei einer Blutung kein Hämatin entstehen, da das Hämoglobin nicht in Kontakt mit Säure kommt.
Ozaena (#R: 0; #F: 2)
Atrophie der Nasenschleimhaut
- häufig Frauen im mittleren Alter

- Eitriges Nasensekret
- Aashafter Gestank aus der Nase
Rhinitis acuta (#R: 0; #F: 2)
Lokale α1-Sympathikomimetika
- Xylometazolin
- Phenylephrin
Pap IVb (#R: 0; #F: 1)
Schwere Dysplasien oder Carcinoma in situ nachweisbar, Invasivität nicht auszuschließen

- Differentialkolposkopie mit Biopsie
Läuferknie (#R: 2; #F: 1)
Tractus-iliotibialis-Syndrom
- Entzündung der Bursa zwischen Tractus iliotibialis und Ansatz am lateralen Epicondylus der Tibia
Akute Angina tonsillaris (#R: 0; #F: 1)
Entzündung der Gaumenmandeln

- Viral: Adeno-, Influenza- und Parainfluenzaviren
- Bakteriell: Streptococcus pyogenes, Staphylokokken, Pneumokokken

Therapie
- Penicillin V
- bei Penicillinallergie: Makrolide (Clarithromycin) oder Roxithromycin
- Tonsillektomie (Nachblutungen aus dem Stromgebiet der A. facialis)
Angina Plaut Vincenti (#R: 0; #F: 1)
- synergistische Mischinfektion mit Treponema vincentii und Fusobacterium fusiforme

- Stets einseitige Veränderung der Gaumenmandel (Ulzerationen)
- Starker Foetor ex ore
Pyoderma gangraenosum (#R: 4; #F: 1)
schmerzhafte Pusteln mit zentraler Nekrose im Rahmen eines Morbus Crohnbevorzugt an der unteren Extremität auftritt und sehr lange zur Abheilung benötigt.
Kocher-Manöver (#R: 2; #F: 1)
Das Kocher-Manöver dient der Mobilisation von Duodenum aus dem Retroperitoneum und ist bei verschiedenen Operationen (Gastrektomie, Ösophagusresektion) ein notwendiger Operationsschritt.
Eptifibatid (#R: -1; #F: 1)
= Thrombozytenaggregationshemmer
= Glykoprotein-IIb/IIIa-Antagonisten
Prävention von arteriellen Embolien

Indikation
- PTCA mit hohem Risiko
- Instabile Angina pectoris

Nebenwirkungen
- Blutungen
Dermatitis herpetiformis Duhring (#R: 4; #F: 1)
• Erythem, Plaques, Bläschen
• Bei atypischer Zöliakie
Spinale Muskelatrophien - hereditär Typ III (#R: 1; #F: 1)
= Kugelberg-Welander

- Manifestation: Zwischen dem 2. und 18. Lebensjahr
- autosomal rezessiv oder autosomal dominant

Symptome
- Symmetrische atrophische Paresen (Beckenmuskulatur/unteren Extremität)
-> Watschelgang
-> Treppensteigen und Aufstehen erschwert
- Später auch Befall der oberen Extremität
- Muskelfaszikulationen

Lebenserwartung ist kaum eingeschränkt
Transversusschwäche (#R: 0; #F: 1)
- Schwäche des M. arytenoideus transversus

- Dorsaler dreieckiger Spalt der Stimmlippen im Bereich der Aryknorpel
Lynch-Syndrom (#R: 6; #F: 1)
Hereditäre nicht polypose Kolonkarzinom

- deutlich erhöhtes Risiko, in mittleren Jahren (45 Jahre) an einem kolorektalen Karzinom zu erkranken.
- erhöhte Wahrscheinlichkeit, an HNPCC assoziierten Karzinomen wie Endometrium-, Ovarial- oder Magenkarzinomen zu erkranken.
Myotone Syndrome (#R: 1; #F: 1)
Tonische Verlängerung der Muskelkontraktion über den Innervationszeitraum hinaus

Symptome
- Muskuläre Startschwierigkeiten nach einer Ruhephase

Klassifikation
1) Nichtdystrophen Myotonien
- Myotonia congenita Thomson
- Paramyotonia congenita Eulenburg
-> Erste Lebensdekade
-> Keine Therapie notwendig

2) Dystrophe Myotonien
- Typ Curschmann-Steinert/DM1 - häufigstes myotones Syndrom!
- Proximaler Typ/DM2
-> Zweite Lebensdekade
-> Lebenserwartung häufig eingeschränkt

Keine Heilung möglich
Hedinger-Syndrom (#R: 8; #F: 1)
Rechtskardial betonte Endokardfibrosierung
- Trikuspidalinsuffizienz
- Pulmonalstenose

- Bei neuroendokrinen Tumoren
Böhler-Zeichen (#R: 1; #F: 1)
Meniskus-Zeichen

- Liegender Patient, leicht gebeugtes Kniegelenk
- Adduktion und anschließende Abduktion des Unterschenkels
- Schmerzen bei Adduktion (Varusstress) → Hinweis auf mediale Meniskusläsion
- Schmerzen bei Abduktion (Valgusstress) → Hinweis auf laterale Meniskusläsion
Meige-Syndrom (#R: 0; #F: 1)
Blepharospasmus + oromandibulärer Dystonie

- Vornehmlich Frauen im 7. Lebensjahrzehnt
Enuresis (#R: 1; #F: 1)
Harninkontinenz des Kindes während der Nacht
Segawa-Krankheit (#R: 0; #F: 1)
= L-Dopa-sensitive Dystonie

- Junge Mädchen

- Gangstörungen
- Flexions- und Innenrotationsstellung der Füße

- Starke Schwankungen der Symptome im Tagesverlauf
- Dystonie nimmt im Laufe des Lebens an Intensität zu

Therapie
- Therapeutisches Ansprechen auf L-Dopa-Gabe
Giggle-Harninkontinenz (#R: 0; #F: 1)
- Sonderform der Dranginkontinenz: Harnblasenentleerung wird durch Lachen getriggert
- Bei Kindern
Debré-de-Toni-Fanconi-Syndrom (#R: 4; #F: 1)
Angeborene oder erworbene unspezifische Tubulopathie des proximalen Tubulus

- Wasserverlust
- gestörte Rückresorption von Aminosäuren, Elektrolyten und Glukose
- Polydipsie
- Polyurie
- Azidose
- Hypokaliämie
- Vitamin-D-resistente Rachitis (im Kindesalter, durch den Phosphatverlust)
Pes equinovarus adductus supinatus et excavatus (#R: 2; #F: 1)
Klumpfuß

- Equinus (Spitzfuß) = Fixierung in Plantarflexion durch Achillessehnenverkürzung
- Varus = Supinationsstellung des Kalkaneus
- Adductus (Sichelfuß) = Abweichen der Zehen nach medial (Vorfußadduktion)
- Supinatus: Supination/Inversion
- Excavatus (Hohlfuß) = Verstärkte Wölbung des Fußes

Beim Klumpfuß stehen Kalkaneus und Talus parallel
Hallux rigidus (#R: 1; #F: 1)
Arthrose des Grundzehgelenks
Sipple-Syndrom (#R: 4; #F: 1)
MEN 2a
• Medulläres Schilddrüsenkarzinom (100%)
• Phäochromozytom (ca. 50%)
Primärer Hyperparathyreoidismus (ca. 20-30%)
Plattenepithelkarzinom (z.B. an Zervix, Vagina, Vulva) - Tumormarker (#R: 1; #F: 1)
SCC - Squamous-cell-carcinoma
SAPHO-Syndrom (#R: 4; #F: 1)
seltene Systemerkrankung aus dem rheumatischen Formenkreis

- Synovitis
- Akne
- Pustulosis
- Hyperostose
- Osteitis.
Epididymitis - Ursachen (#R: 1; #F: 1)
- Chlamydien
- Neisserien
- TBC

- Amiodaron
Cadmium (#R: 2; #F: 1)
Klinik
- Gelbliche Zahnhälse
- Nierenschäden (tubulo-interstitielle Nephritis), Nierenzellkarzinom
- Lungenerkrankungen (Emphysem, Karzinom)
- Anosmie
- Osteoporose/-malazie

Diagnostik
- Akute Belastung: Cadmium im Blut
- Chronische Belastung: Cadmium und β2-Mikroglobulin im Urin

Sonstiges
- Itai-Itai-Krankheit (Nierenversagen und Osteomalazie)
- In Zigaretten

Therapie
- D-Penicillamin
Varikozele testis (#R: 0; #F: 1)
Gefäßkonvolut im Skrotum

- Schmerzlose Vergrößerung des Skrotums
- Missempfindung durch Größenzunahme möglich
- Verbesserung des Lokalbefundes durch Lageänderung ("Hinlegen") bei idiopathischer Varikozele

- linksseitig = meist idiopathisch (verschwindet bei Lageänderung)
- rechtsseitig = meist sekundär
Beckwith-Wiedemann-Syndrom (EMG-Syndrom) (#R: 5; #F: 1)
- Omphalozele
- Hemihypertrophie
- relative Mikrozephalie
- Makroglossie
- auffällige Ohrform
- Hypoglykämien.
N. XII (#R: 0; #F: 1)
Nervus hypoglossus

Zunge herausstrecken
- Abweichung zur kranken Seite bei Nervenausfall durch ein Überwiegen der Muskulatur der gesunden Seite.

Zunge von innen in die Wange drücken lassen und Kraftprüfung von außen
Vanadium (#R: 2; #F: 1)
Klinik
- Grünschwarze Verfärbung der Zunge und der Zigarettenstummel bei Rauchern
- Schleimhautreizung, Bronchitis und Bronchopneumonie
- Lungenfibrose
- Hartmetalllunge

Diagnostik
- Nachweis im Urin oder Blut
Silver-Russell-Syndrom (#R: 0; #F: 1)
- intrauteriner Kleinwuch

- dreieckig wirkendes Gesicht
- - hohe Stirn
- - herabhängende Mundwinkel
- - spitzes Kinn.
Charcot-Trias II (#R: 1; #F: 1)
- Rechtsseitiger Oberbauchschmerz
- Ikterus
- Fieber
Priapismus (#R: 1; #F: 1)
venösen Stase in den Corpora cavernosa

- chronische myeloische Leukämie
- kokain, alkohol, ...
Nichtorganische Schlafstörungen (#R: 0; #F: 1)
1) Nichtorganische Insomnie
Ungenügende Dauer und Qualität des Schlafes
- Einschlafstörungen
- Durchschlafstörungen
- Frühmorgendliches Erwachen

-> Assoziationen
- Depression
- Angststörungen, etc.

2) Parasomnien
Schlafstörungen aus dem Schlafheraus, häufig bei Kindern
- Schlafwandeln
- Pavor nocturnus
- Albträume

-> nicht pathologsich

Therapie
- Schlafhygiene
1) Benzodiazepinähnliche Hypnotika
- Zolpidem
- Zopiclon
- Zaleplon
2) Niedrigpotente Antipsychotika
- Levomepromazin
3) Sedierende Antidepressiva
- Mirtazapin
- Trimipramin
4) Melperon
- Insbesondere bei alten Patienten, Demenzen und Morbus Alzheimer
Aromatische Amine (#R: 2; #F: 1)
- Diaminodiphenyl
- β-Naphthylamin

Urothelkarzinom der Harnblase
→ Schmerzlose Makrohämaturie gilt als Hinweis
metachromatische Leukodystrophie (#R: -1; #F: 1)
Lipidspeicherkrankheit
- Defekt der Arylsulfatase A
- Sphingolipide können nicht gespalten werden -> akkumulieren
- Nerven- Demyelinisierung

- Paresen
- Visusverlust (durch Atrophie des N. opticus)
- mentale Retardierung
Trizepssehnenreflex (TSR) (#R: 1; #F: 1)
C6-C8

Der Untersucher hält den Arm des Patienten im angewinkelten Zustand und klopft mit dem Reflexhammer auf die Trizepssehne, wodurch eine Extension im Ellebogengelenk ausgelöst wird.
Adduktorenreflex (#R: 1; #F: 1)
L2-L4

Zu einer Adduktionsbewegung der Beine kommt es beim Beklopfen der Sehnen oberhalb des Condylus medialis femoris.
Dimethylformamid (#R: 2; #F: 1)
Klinik
- Toxische Hepatopathie (Fettleber)
Onkozytom (#R: 1; #F: 1)
Hürthle-Adenom

- gutartiger epithelialer Tumor
- Brauner Tumor mit zentraler, sternförmiger Vernarbung
- eosinophile, mitochondrienreiche Zellen
Benigne Prostatahyperplasie (#R: 1; #F: 1)
Alpha-Rezeptor-Blocker
- Alfuzosin
- Tamsulosin
- Doxazosin

5-alpha-Reduktasehemmer
- Finasterid
Urothelkarzinom (#R: 0; #F: 1)
Risikofaktoren
- Nikotinabusus
- aromatische Amine (z.B. β-Naphthylamin)
- Chronische Zystitiden

- Häufig papillärer / blumenkohlartiger Tumor
- Solide Ausprägungen bei fortgeschrittenen Stadien
- Häufig multizentrisches Auftreten
- Häufigste Lokalisation an der Harnblasenhinterwand und -seitenwand
Smith-Lemli-Opitz-Syndroms (#R: 0; #F: 1)
• Mangel an 7-Dehydrocholesterol-Reduktase zugrunde, der zu einem Mangel an Cholesterin und einer Akkumulation von 7-Dehydrocholesterol im Plasma
Kleinwuchs, Lidptose, kurzer Nase mit aufgerichteten Nasenlöchern, Syndaktylie Hypospadie
Seminom (#R: 0; #F: 1)
- Häufigster Tumor (40-55%) unter den Hodentumoren
- Makroskopisch einheitlich weiße Färbung nach Anschnitt
- Fakultative Produktion von β-HCG
- Keine Produktion des Alpha-Feto-Proteins
Schwefelwasserstoff (#R: 2; #F: 1)
Klinik
- Lungenödem
- Rascher Riechverlust
- Hämoglobinzerstörung
- Hornhauttrübung
- chronische Bronchitis
Kugelberg-Welander-Krankheit (#R: 0; #F: 1)
spinale Muskelatrophie (Typ Kugelberg-Welander) wird meist autosomal-rezessiv vererbt und ist durch eine nicht-entzündliche Degeneration des 2. Motoneurons gekennzeichnet.
Katathyme Amnesie (#R: 0; #F: 1)
Unbewusstes Vergessen einzelner Gedächtnisinhalte
Molimina menstrualia (#R: 0; #F: 1)
Amenorrhö, die monatlich an Schmerzintensität zunimmt
Kehr-Zeichen (#R: 1; #F: 1)
Schmerzausstrahlung in die linke Schulter
- Milzruptur
- Tubenruptur
Azoospermie (#R: 1; #F: 1)
Keine Spermatozoen im Ejakulat
Zuelzer-Wilson-Syndrom (#R: 0; #F: 1)
Komplette Aganglionose des Kolons
testikuläre Feminisierung (#R: 1; #F: 1)
Genotyp männlich, der Phänotyp weiblich

komplette Androgenresistenz. Meist liegt eine (hoch-)normale Androgenkonzentration vor, jedoch sind die Androgenrezeptoren bzw. der nachfolgende Signalweg derart pathologisch verändert, sodass die Androgene am Endorgan keine Wirkung entfalten können.

Bei der testikulären Feminisierung findet sich ein weibliches äußeres Genital in Kombination mit intraabdominellen Hoden und fehlenden inneren, weiblichen Geschlechtsorganen (blind endende Vagina, fehlender Uterus und Ovarien) sowie einer fehlenden sekundären Geschlechtsbehaarung.
Cimetidin (#R: -1; #F: 1)
H2-Antihistaminika (#R: 0; #F: 0)
Kompetitiver Antagonismus am Histamin-H2-Rezeptor

Vertreter
1) Ranitidin
2) Cimetidin

Indikation
- Senkung der Magensäureproduktion (2. Wahl)
- Zusätzlich zu H1-Antihistaminika bei anaphylaktischem Schock
Alagille-Syndroms (#R: -1; #F: 1)
- intrahepatische Gallenganghypoplasie
- Augenfehlbildung
- Gesichtsdysmorphie
- Herzvitium (periphere Pulmonalstenosen)
- Skelettanomalien (Schmetterlingswirbelkörper)
Sekundäreffloreszenz (#R: 2; #F: 1)
#Squama Hornschichtlamelle, die sich in Ablösung befindet
#Crusta Eingetrocknetes Sekret (Serum, Blut, Eiter)
#Ulkus Tiefer Gewebedefekt bis in die Dermis oder Subkutis
#Erosion Oberflächlicher Gewebedefekt
#Exkoriation Oberflächlicher Gewebedefekt mit Blutung (bis in die obere Dermis reichend)
#Nekrose Abgestorbenes Hautgewebe
#Atrophie Geweberückbildung ohne vorangegangenen Substanzdefekt
#Cicatrix Abgeheilter Gewebedefekt im Hautniveau mit minderwertigem Gewebeersatz. Bildung von Keloid möglich
Dislocatio ad peripheriam (#R: 1; #F: 1)
Verdrehung um die Längsachse
Ekthyma (#R: 2; #F: 1)
Superinfektion kleiner Verletzungen meist durch ß-hämolysierende Streptokokken. Sie manifestiert sich als münzengroßes, scharf begrenztes und oberflächliches Ulcus, das wie ausgestanzt wirkt.
M. Behçet (#R: 3; #F: 1)
Systemische Vaskulitis mit multipler Organbeteiligung

- Orale Aphten
- Genitalen Aphthen
- Augen- und Hautveränderungen
- Arthritiden
- aseptische Meningitis
- Sinusvenenthrombose
Clomifen (#R: 0; #F: 1)
selektiver Östrogen-Rezeptor-Modulator

- anti-östrogene Wirkung
- vermehrten FSH/LH-Freisetzung mit künstlichem FSH/LH-Peak führt. Die hohen Spiegel können bei intakter Hypothalamus-Hypophysen-Ovar-Achse eine Follikelreifung und eine Ovulation bewirken
Kortikobasale Degeneration (#R: 1; #F: 1)
- Hemiparkinson-Syndrom
- eine Extremität vom Patienten als fremd wahrgenommen (alien limb)
Epiphysenfugenverletzung - Aitken 0 und I - Therapie (#R: 1; #F: 1)
Ruhigstellung im Gips
Lewy-Body-Demenz (#R: 1; #F: 1)
Neurodegenerative Demenz mit histopathologischem Korrelat kortikaler und limbischer Lewy-Einschluss-Körperchen

- niedriges Alter bei Erkrankungsbeginn
- rasche Progredienz
- Kognitive, demenzielle Defizite
- Visuelle Halluzinationen und paranoide Episoden
- Extrapyramidalmotorische Symptome (Bradykinese, Rigor)

KEINE Neuroleptika!
Außenknöchelfraktur - fehlstellung (#R: 2; #F: 1)
Valgusfehlstellung
Madarosis (#R: 2; #F: 1)
Wimpernausfall
Schraubenosteosynthese (#R: 1; #F: 1)
Interfragmentäre Kompression bei Verwendung als Zugschraube
Erythema infectiosum (#R: 3; #F: 1)
= Ringelröteln
- Parvovirus B19

- schmetterlingsförmiges Erythems des Gesichts
- im Verlauf girlandenartige Erytheme am Körper
Staphylococcal scalded skin syndrome (#R: 3; #F: 1)
lebensbedrohliche, blasenbildende Erkrankung
- Staphylokokken-Toxin
- Abhebung der Haut

- vor allem Säuglinge und Kleinkinder
- immungeschwächte Erwachsene

- hohes Fieber
- diffuse Rötung des ganzen Körpers
- Bildung von schlaffen, leicht reißenden Blasen

- Kein Befall der Schleimhaut (Abgrenzung zum Stevens-Johnson-Syndrom!)
Fixateur interne (#R: 1; #F: 1)
Stabilisierung der Wirbelsäule durch dorsale osteosynthetische Versorgung
Segawa-Syndrom (#R: 1; #F: 1)
Dopa-responsive Dystonie
- Sonderform einer generalisierten Dystonie
- phasenweise, unkontrollierbare Muskelkontraktionen
- junge Mädchen im ersten Lebensjahrzehnt

- Gangstörung
- Flexions- und Innenrotationsstellung der Füße
- starke Schwankungen im Tagesverlauf

- spricht gut auf L-Dopa-Gabe an
Keratoma sulcatum (#R: 2; #F: 1)
= Keratolysis sulcata plantaris

- Mazeration mit Eindringen von Bakterien an der Fußsohle
- grübchenförmiger, stark brennender Hornhautdefekt

- Sportler, Arbeiter oder Soldaten mit okklusivem Schuhwerk.
Chopart-Gelenkluxation (#R: 1; #F: 1)
Das Chopart-Gelenk setzt sich aus Kalkaneokuboidgelenk und Talonavikulargelenk zusammen. Bei einer Luxation kommt es zur Verschiebung des gesamten Vorfußes.
Refsum-Syndrom (#R: 1; #F: 1)
hereditäre motorisch-sensible Neuropathie (HMSN)

- Ataxie
- Retinopathia pigmentosa
- Ichthyosis
- Taubheit
Demodikose (#R: 2; #F: 1)
Die Demodikose betrifft meist Frauen und gehört zu den rosazeaartigen Erkrankungen. Hervorgerufen durch Besiedlung der Talgdrüsenfollikel mit Milben (Demodex folliculorum) kommt es zu einseitiger papulopustulöser Veränderung an Wangen und Augenlidern.
Munro-Mikroabszesse (#R: 2; #F: 1)
nsammlungen neutrophiler Leukozyten innerhalb der Hornschicht bei der Psoriasis vulgaris.
Curschmann-Steinert-Erkrankung (#R: 1; #F: 1)
Myotone Dystrophien
- autosomal-dominant
- Trinukleotid-Repeat-Erkrankung -> Antizipationseffekt
- Defekt der Myotonin-Proteinkinase
-> in Skelett- und Herzmuskulatur, Gonaden und Gehirn

1) Kongenitale Form: Säuglingsalter
2) Adulte Form: 20.-30. LJ.

Lokalisation
- Distale Extremitäten
- Gesicht
- Nacken

- Stirnglatze
- Hodenatrophie/Ovarialinsuffizienz
- Demenz
Stiff-Person-Syndrom (#R: 1; #F: 1)
Das Stiff-Person- oder auch Stiff-Man-Syndrom ist eine Autoimmunerkrankung mit Antikörpern gegen die Glutamat-Decarboxylase (in 60-90% der Fälle) oder gegen Amphiphysin.
Pinguecula (#R: 2; #F: 1)
Harmlose Degeneration der Bindehaut

- leicht erhabener grau-gelblicher Fleck
- meist am nasalen Hornhautrand
Louis-Bar-Syndrom (#R: 1; #F: 1)
Phakomatose
- im Kindesalter

- Ataxie
- faziale und konjunktivale Teleangiektasien
- okulomotorische Störungen
- kognitiven Störungen
- verminderte Immunkompetenz
akute intermittierende Porphyrie (#R: 2; #F: 1)
- Enzymdefekt
- Störung der Häm-Biosynthese

Symptome
- kolikartiger Abdominalschmerz
- periphere Paresen
- Psychosen
- Tachykardie
- epileptische Anfälle

- Urin rötlich gefärbt
- dunkelt beim Stehenlassen nach
Could you give me some smaller notes? http://nudevista.in.net/ nudevista com “After doing two years in prison, trust me, I’ve seen a lot of tough guys pray,” he said. “They’re not just praying for themselves; they’re praying for their family and the people they’ve let down.” (#R: -1; #F: 1)
Could you give me some smaller notes? http://nudevista.in.net/ nudevista com “After doing two years in prison, trust me, I’ve seen a lot of tough guys pray,” he said. “They’re not just praying for themselves; they’re praying for their family and the people they’ve let down.”
Rockwood V (#R: 1; #F: 1)
wie Tossy III, zusätzlich Abrissverletzung des M. deltoideus sowie M. trapezius vom distalen Ende der Klavikula
Opsoklonus-Myoklonus-Syndrom (#R: 0; #F: 1)
Enzephalitis des Hirnstamms

- Opsoklonien (unwillkürliche Zuckungen der Augen)
- Myoklonien (Muskelzuckungen)
- Ataxie äußert

häufig paraneoplastisch
- bei Kindern: Hirntumore
- bei Erwachsenen: Mamma- und Bronchialkarzinome
Abortivei (#R: 1; #F: 1)
Molenschwangerschaft

- intakter Trophoblast und Eihüllen
- Entwicklungsstörung der Plazentazotten
- konsekutiver Fruchttod (Absterben der Embryonalanlage).
Kongenitale Melanose (#R: 1; #F: 1)
gutartige, angeborene Pigmentierung der Episklera

- nicht mit der Bindehaut verschieblich
- subepithelial
Mittelhirnsyndrom (#R: 2; #F: 1)
Ausfall der Formatio reticularis und Einklemmung der Zentren für den visuellen Lichtreflex

- Überstreckung von Rumpf und allen Extremitäten, Arme adduziert und innenrotiert, Finger gebeugt→ sogenannte Dezerebrationshaltung
- Erhöhter Muskeltonus mit gelegentlichem Opisthotonus
- Pupillenreflexe träge oder nicht mehr vorhanden
- Lebhafte Muskeleigenreflexe
- Pathologische Reflexe
- Tachypnoe (Maschinenatmung)
dyshidrotische Dermatitis (#R: 2; #F: 1)
Die dyshidrotische Dermatitis ist meist durch ein toxisches, seltener durch ein allergisches Kontaktekzem bedingt, sie kann aber auch im Rahmen der atopischen Dermatitis auftreten. Kennzeichnend sind kleine, juckende Bläschen an Hand- und Fußinnenseiten sowie an den Fingerseitenflächen.
Arcus lipoides (#R: 2; #F: 1)
Altersbedingte ringförmige Ablagerungen von Lipiden am Hornhautrand
Garden-Klassifikation (#R: 1; #F: 1)
Garden I
- Inkomplette, eingestauchte Fraktur mit Valgusstellung, ohne Dislokation
- konservativ

Garden II
- Vollständige Fraktur ohne Dislokation
- operativ

Garden III
- Vollständige Fraktur mit teilweiser Dislokation
- operativ

Garden IV
- Vollständige Fraktur mit kompletter Dislokation
- operativ
Bakterielle Keratitis (#R: 1; #F: 1)
Häufigste Form der Keratitis (ca. 90%)
- Staphylokokken, Streptokokken, Moraxella, Pseudomonas aeroginosa, Proteus mirabilis

- Pseudomonas aeroginosa: Fulminanter Verlauf mit schweren Ulzerationen

- Progrediente Schmerzen
- Fremdkörpergefühl
- Eitriges Sekret
- Photophobie

- Keratitis punctata superficialis: Punktförmige Läsionen im Hornhautepithel
- Gefäßeinsprossung in die Hornhaut
- Vernarbungen der Hornhaut
- Perforation

- Glukokortikoide kontraindiziert
Ataxia teleangiectatica Louis-Bar (#R: 2; #F: 1)
- Phakomatose
- autosomal-rezessiv

- zerebelläre Ataxie
- faziale und konjunktivale Teleangiektasien
- okulomotorischen und kognitiven Störungen
- verminderte Immunkompetenz
Pemphigus vulgaris (#R: 2; #F: 1)
seltene Autoimmundermatose (IgG-Autoantikörper gegen Desmoglein), die sich eher im mittleren bis höheren Alter manifestiert. Dabei entstehen intraepidermale, schlaffe Blasen mit serösem Inhalt, die aufplatzen und ohne Vernarbung abheilen.
Risikoschwangerschaft (#R: 1; #F: 1)
Alter bei Erstschwangerschaft 35 Jahre
Familiäre Belastungen: U.a. Fehlbildungen, genetische Erkrankungen, Hypertonie, Diabetes mellitus, Häufung von Schwangerschafts- und Geburtskomplikationen
Vorerkrankungen der Mutter: U.a. Hypertonie, Diabetes mellitus, Malignome, Infektionen, neurologische Erkrankungen
Uterusanomalien: Myome, Z.n. nach Uterusoperation, Z.n Sectio
Schwangerschaftsanamnese
>5 Geburten
>2 Aborte oder Abruptios
Z.n. Frühgeburt, Totgeburt oder Geburt eines geschädigten Kindes
Z.n. Geburt eines hyper- oder hypotrophen Kindes
Z.n. Mehrlingsschwangerschaft
Z.n. Geburtskomplikationen
Z.n. Sectio caesarea oder anderen Uterusoperationen
Z.n. Sterilitätsbehandlung
Z.n. Rhesusinkompatibilität
Rasche Schwangerschaftsfolge (
Rolando-Epilepsie (#R: 0; #F: 1)
- Häufigste Epilepsie des Kindesalters
- Altersgipfel: 5.-9. Lebensjahr

- Meist schlafgebundene
- tonische Gesichtskrämpfe
- vermehrte Salivation
- Sprachunfähigkeit

EEG
- Zentrotemporale sharp waves

- Heilt in der Regel mit Erreichen der Pubertät aus
Pronation/Supination des Unterarms (#R: 2; #F: 1)
90/0/90
N. IV (#R: 0; #F: 1)
- M. obliquus superior

- Schräg stehende, vertikale Doppelbilder
- stärkste Doppelbilder beim Blick nach nasal unten (z.B. beim Lesen)

Bielschowsky-Phänomen
- Größte Schielabweichung bei Kopfneigung zur Seite des paretischen Muskels
-> Kompensatorisch Kopfneigung zur Gegenseite
Untersuchungen des Meniskus (#R: 1; #F: 1)
- Steinmann-I-Zeichen
- Steinmann-II-Zeichen
- Böhler-Zeichen
- Payr-Zeichen
- Apley-Grinding-Zeichen
Adie-Syndrom (#R: 1; #F: 1)
Pupillotonie und Areflexie der unteren Extremität
Untersuchungen des Hüftgelenks (#R: 1; #F: 1)
- Vierer-Zeichen
- Thomas-Handgriff
- Drehmann-Zeichen
- Trendelenburg-Zeichen
- Duchenne-Zeichen
- Hinge abduction
Syneresis (#R: 1; #F: 1)
Zunehmende Verflüssigung des Glaskörpers durch degenerative Prozesse

- Meist asymptomatisch
- Mouches volantes
Foramen rotundum (#R: 1; #F: 1)
Schädigung des N. maxillaris (2. Ast des Nervus trigeminus)
Glaskörperblutung (#R: 1; #F: 1)
plötzlich erscheinende schwarze Trübungen oder Visusverlust

Ätiologie
- hintere Glaskörperabhebung
- Proliferative diabetische Retinopathie
- Ischämischer retinaler Venen(ast)verschluss
- Altersbedingte Makuladegeneration
- Subarachnoidalblutung (Terson-Syndrom)
Präeklampsieprophylaxe (#R: 1; #F: 1)
ASS
Hinweise auf Hyperlordose (#R: 1; #F: 1)
Baastrup-Phänomen
- Kontakt benachbarter Dornfortsätze der LWS
Creutzfeldt-Jakob-Krankheit (#R: 0; #F: 1)
Nicht-entzündliche, degenerative Enzephalopathie
- fehlgefaltete Proteine (Prionen)
- Latenz nach Infektion bis zu 30 Jahren
- Rasch letal, keine kausale Therapie verfügbar

Symptomen
- Appetit- und Schlaflosigkeit
- Rasche Demenzentwicklung
- Myoklonien
- zerebellären Störungen (Ataxie)
- psychiatrischen Auffälligkeiten
- akinetischer Mutismus

Histologie
- Spongiöses Hirngewebe

EEG
- triphasische Sharp-wave-Komplexe
Elsberg-Syndrom (#R: 0; #F: 1)
- Radikulomyelitis
- ähnlich Konus-Kauda-Syndrom

Es ist fraglich, ob hier eine eigene Krankheitsentität vorliegt.
Arthrosezeichen (#R: 2; #F: 1)
- Verschmälerung des Gelenkspalts
- Subchondrale Sklerose
- Osteophyten
- Geröllzysten Subchondrale
- Keine Osteoporose!
Retinopathia pigmentosa (#R: 1; #F: 1)
Progrediente, erbliche Dystrophie der Netzhaut bzw. der Photorezeptoren und des retinalen Pigmentepithels
- Früher Beginn (5.-30. Lebensjahr)

- Nachtblindheit
- Röhrenförmige Gesichtsfeldeinengung (Flintenrohrgesichtsfeld)
- Blendempfindlichkeit
- Störung des Kontrast- und Farbensehens
- In späten Stadien Visusminderung, in frühen Stadien gute zentrale Sehschärfe
Morbus Stargardt (#R: 1; #F: 1)
Juvenile Makuladystrophie, vom retinalen Pigmentepithel ausgehend
- Chronisch progrediente Visusverschlechterung
- Beginn zwischen dem 10. und 30. Lebensjahr
- autosomal-rezessiv
- schlechte Prognose
angeborene Unterschenkelpseudarthrose (#R: 1; #F: 1)
- einseitige Verbiegung von Tibia und Fibula nach außen

Dabei ist eine Unterschenkelpseudarthrose (Falschgelenkbildung von Tibia und Fibula) bei Geburt vorhanden oder entsteht abhängig vom Grad der Verkrümmung im Verlauf.

Es besteht eine Assoziation zur Neurofibromatose I.
Meralgia paraesthetica (#R: 1; #F: 1)
Eine Reizung des N. cutaneus femoralis lateralis führt charakteristischerweise zu einer hypästhetischen Zone im Versorungsgebiet des Nervs. Meist sind davon adipöse Menschen oder Schwangere betroffen.
I. Stellung (#R: 1; #F: 1)
- Die kleine Fontanelle, die sich am kindlichen Hinterkopf befindet, liegt zur linken Seite der Mutter hingewandt.

- Der kindliche Rücken liegt (von der Mutter aus betrachtet) links

-> Vordere Hinterhauptslage
II. Stellung (#R: 0; #F: 1)
- kleine Fontanelle rechts
- Rücken rechts

-> Vordere Hinterhauptslage
Zentralarterienverschluss (#R: 1; #F: 1)
Plötzliche einseitige, schmerzlose Erblindung / Visusverlust / Skotome

Funduskopie
- abgeblasste, ödematöse Netzhaut
- kirschroter Fleck im Bereich der Fovea
Ependymom (#R: 2; #F: 1)
Aus den Ependymzellen der Hirnventrikel wachsender Tumor (WHO I-IV)
- Kinder bis junge Erwachsene

Lokalisation
- ⅔ im 4. Ventrikel

Symptome
- Dauerkopfschmerz
- Evtl. Verschlusshydrozephalus

CT
- Hyperdenser Tumor nach KM-Gabe

Histologie
- Perivaskuläre Tumorzellgruppierungen = Pseudorosetten

Lumbalpunktion
- Abtropfmetastasen

Therapie
- Resektion
- Radiatio
Chiasmasyndrom (#R: 1; #F: 1)
- bitemporale Gesichtsfeldausfälle
- Sehschärfereduktion
- Optikusatrophie
Osteochondrom (#R: 2; #F: 1)
Von Knorpelkappe bedeckter Tumor im Metaphysenbereich

- Häufigster primär benigner Tumor
- Häufigkeitsgipfel: 1.-2. Lebensdekade
- Lokalisation: Metaphyse langer Röhrenknochen
- Klinik: Meist keine Symptome
Lorazepam (#R: -1; #F: 1)
Benzodiazepin
langwirksam

Angst- und Panikattacken
Spannungszustände
Akute paranoide Episoden
Muskelrelaxierung
Epilepsien
Alkoholentzugssyndrom

hohes Abhängigkeitspotential
Osteom (#R: 2; #F: 1)
- Gutartiger rundlicher Knochentumor

- Jedes Lebensalter
- Schädel (Nasennebenhöhlen) + Lange Röhrenknochen

Klinik
- Keine Symptome

Therapie
- Keine
Nicht-ossifizierendes Knochenfibrom (#R: 1; #F: 1)
Tumorähnliche häufige Raumforderung

- Vorkommen im Rahmen von Wachstumsstörungen
- fast immer im 2. Lebensjahrzehnt
- Metaphysär, sehr häufig distaler Femur und distale Tibia

Klinik
- Keine Symptomatik

Konventionelles Röntgen
- Randständige Sklerose, lobulierte Binnenstruktur mit Aufhellung (Traubenkonfiguration)
Meningokokken-Impfung (#R: 1; #F: 1)
Totimpfstoff

Polysaccharid oder Konjugatimpfstoff
- Subtypen A, C, W135 und Y

Konjugatimpfstoff g
- Subtyp C (zweithäufigster Typ in Deutschland)

Routinemäßig im 2. Lebensjahr: Einmalige Impfung gegen Typ C
Osteosarkom (#R: 2; #F: 1)
Bösartiger Tumor, der von polymorphen, knochenbildenden Zellen ausgeht

- 16.-25. Lebensjahr
- Häufigster primär maligner Knochentumor
- Assoziation mit Retinoblastom
- 60% kniegelenksnahe Metaphysen
- Metastasierung: Hämatogen! Erst Lunge, dann Skelett

- neoadjuvante Chemotherapie + radikale Resektion

- Der Tumor ist strahlenresistent!
- 5 Jahresüberlebensrate ca. 50-70%
Adrenalin (#R: -1; #F: 1)
= Sympathomimetika

- Kardiopulmonale Reanimation
- Anaphylaxie
Negativer Rinne-Versuch (#R: 0; #F: 1)
Luftleitung nicht besser als Knochenleitung → Hinweis für eine Mittelohrschädigung (Schallleitungsschwerhörigkeit) des getesteten Ohrs
Polymyalgia rheumatica (#R: 0; #F: 1)
- symmetrische Schmerzen + Morgensteifigkeit des Schulter- und Beckengürtels
- Fieber
- Gewichtsverlust
- depressive Verstimmung

- stark erhöhte BSG
- CRP-Erhöhung
- Leukozytose + Anämie
- normwertige CK

- ältere Frauen

DD Polymyositis (hohe CK!)
Dermatomyositis (#R: 0; #F: 1)
Die Dermatomyositis gehört zur Gruppe der Kollagenosen. Hierbei zeigen sich entzündliche Veränderungen an Schulter- und Beckenmuskulatur mit begleitender Muskelschwäche und Schmerzen, sowie erythematöse lilafarbene Hauterscheinungen ("Lila-Krankheit"). In der laborchemischen Untersuchung würde man als Leitbefund eine deutliche Erhöhung der Kreatinkinase (CK) erwarten - eine normwertige CK spricht für eine andere Diagnose. Insbesondere bei älteren Patienten kann die Dermatomyositis Ausdruck eines paraneoplastischen Syndroms sein.
Morbus Sinding-Larsen-Johansson (#R: 1; #F: 1)
aseptische Knochennekrose im Bereich des distalen Patellapols
Fibromyalgie-Syndrom (#R: 0; #F: 1)
Chronisches Schmerzsyndrom

- schmerzhafte Druckpunkte ("tender points")
- vegetative Symptome
- funktionelle Beschwerden

- häufig Frauen

- keine Laborveränderungen!
Gellé positiv (#R: 1; #F: 1)
Mittelohr gesund oder Prozess im Mittelohr ohne Einschränkung der Beweglichkeit der Gehörknöchlchen
Morbus Osgood-Schlatter (#R: 0; #F: 1)
Aseptische Knochennekrose

- Tuberositas tibiae (extraartikulär!)
- Alter: 9-13
- ♂>♀ (10:1)
- Sportler
- Gute Prognose bei konservativer Therapie
Gellé negativ (#R: 0; #F: 1)
Hinweis für Otosklerose
Morbus Ahlbäck (#R: 0; #F: 1)
Aseptische Knochennekrose

- mediale Femurkondyle
- Alter: 60-70
- meist ältere, weibliche Patienten
Morbus Panner (#R: 1; #F: 1)
Aspetische Knochennekrose

- Capitulum humeri
- Alter: 6-10
- Gute Prognose bei konservativer Therapie
β-Thalassaemia (#R: 0; #F: 1)
Adultes Hämoglobin (HbA) besteht aus 2 α- und 2 β-Globinketten. Bei der β-Thalassämie liegt eine ineffektive Erythropoese mit Störung der β-Globinkettensynthese vor. Die Folge ist eine reaktiv gesteigert Produktion von γ- und δ-Globinketten. Dabei wird vermehrt fetales Hämoglobin (HbF) gebildet, was aus 2 α- und 2 γ-Globinketten besteht.
Capsula interna - Infarkt (#R: 1; #F: 1)
- Kontralaterale Hemiparese
- kontralaterale Hirnnervenausfälle
paroxysmale nächtliche Hämoglobinurie (#R: 0; #F: 1)
Die Ursache hier ist eine Genmutation auf dem X-Chromosom, die zu einer monoklonalen Störung der hämatopoetischen Stammzellen führt. Diese Störung wiederum kann in ein myelodysplastischen Syndrom oder eine aplastische Anämie übergehen. Die Erkrankung an sich mündet in einer massiven Hämolyse, bei der Hämoglobin freigesetzt wird. Freies Hämoglobin bindet den Vasodilatator und Thrombozytenhemmer Stickstoffmonoxid (NO). Weiterhin führen die Erythrozytenfragmente (genauer gesagt der Kontakt zur inneren Membran) zu einer Aktivierung der Thrombozyten mit der Folge einer deutlich erhöhten Thromboseneigung.
M. Werlhof (#R: 1; #F: 1)
idiopathischer thrombozytopenischer Purpura
aplastische Anämie (#R: 0; #F: 1)
Die Ursache einer aplastischen Anämie ist eine Insuffizienz des Knochenmarks unterschiedlicher Genese. Das insuffiziente Knochenmark führt zu einer Panzytopenie, die eine erhöhte Infektanfälligkeit und Blutungsneigung sowie eine Anämie bedingt.
Vertebrobasiläre Insuffzienz (#R: 0; #F: 1)
- Drehschwindel
- drop-attacks
- Tinnitus
- Sehstörungen
Steppergang (#R: 1; #F: 1)
Ausfall des N. fibularis profundus
Otitis externa maligna (#R: 0; #F: 1)
Nekrotisierende Entzündung des äußeren Gehörgangs
- Pseudomonas aeruginosa
- Ältere Diabetiker

- Früh Ausfall von Hirnnerven, hauptsächlich Fazialislähmung
- Übergreifen auf den Knochen möglich

- Piperacillin + Tobramycin (Aminoglykosid)
Scherengang (#R: 2; #F: 1)
spastische Tonuserhöhung der Adduktorenmuskulatur des Hüftgelenks bei Para- bzw. Tetraparese

Überkreuzen der Beine während des Gehens
frühkindliche Oligoarthritis (#R: 0; #F: 1)
In etwa 50% der Fälle tritt die (frühkindliche) Oligoarthritis gemeinsam mit einer chronischen Iridozyklitis (=Uveitis anterior) auf, die häufig zunächst symptomarm beginnt.
chronischen Otitis media (#R: 0; #F: 1)
- Otitis media chronica mesotympanalis
- Cholesteatom
- Tympanosklerose
Aktinomykose (#R: 1; #F: 1)
- bakterielle Mischinfektion mit Aktinomyzeten (anaerob)
- Drusen (eitrige kleine Körnchen)
- eitrigen Fistelgängen

Therapie
- Aminopenicilline (1. Wahl)
- alternativ: Tetrazykline oder Cephalosporine
Coxa antetorta (#R: 2; #F: 1)
Antetorsionswinkel >20°

- Innenrotiertes Gangbild, bei dem die Fußspitzen nach innen zeigen
- Bei etwa 15% Kinder physiologisch im Wachstumsalter
- Bildet sich meist spontan zurück
Chronisches Seromukotympanum beim Kind (#R: 0; #F: 1)
Sekretansammlung in der Paukenhöhle (Paukenerguss) > 3 Monate

- Transparenzminderung des Trommelfells
- gelblich schimmerndes Trommelfell (Trommelfell intakt)
- Feine radiäre Gefäßinjektion des Trommelfells
- Retrahiertes Trommelfell
Akutes Seromukotympanum beim Erwachsenen (#R: 0; #F: 1)
- Nasopharynx-Karzinom
- Rhinitis, Sinusitis, Pharyngitis
- Rezidivierende Otitis media
Schultereckgelenksprengung Typ III nach Tossy (#R: 1; #F: 1)
Ruptur der Ligg. acromioclaviculare und coracoclaviculare zum Hochstand der lateralen Klavikula. Dieser Zustand wird auch als Klaviertastenphänomen bezeichnet.
Otosklerose (#R: 1; #F: 1)
zunehmende Verknöcherung des Labyrinthes

- Hauptmanifestationsort: Steigbügel
- Schallleitungsschwerhörigkeit
- Tinnitus
- Im Verlauf bei 70% der Patienten zweites Ohr betroffen
- Zunahme der Symptome bei hormonellen Umstellungen während oder nach der Schwangerschaft

- Fehlender Stapediusreflex
- Carhart-Senke der Knochenleitungsschwellenkurve bei 2000 Hertz

Therapie
- Stapedotomie / Stapedektomie => Prothese
- Cochlea-Implantat
Harnleiterkolik (#R: 1; #F: 1)
harakteristisch sind kolikartige Schmerzen im Unterbauch und Schmerzausstrahlung in Flanke, Leiste und Genitalregion. Zusätzlich kann reflektorisch ein paralytischer Subileus entstehen. Auch das beschriebene unruhige Umhergehen des Patienten ist typisch.
Migräne (#R: 0; #F: 1)
- 60% einseitiger Kopfschmerz
- insbesondere frontal, frontotemporal, retroorbital
- Dauer: 4-72 Stunden

- Verstärkt bei körperlicher Aktivität
- Übelkeit, Erbrechen
- Phonophobie
- Photophobie

Aura-Phänomenen (15%)
- Gesichtsfeldausfälle (Flimmerskotome) von parazentral nach peripher wandernd
- Paresen

Akut-Therapie
- NSAR (ASS, Ibuprofen, Paracetamol)
- Triptane (Sumatriptan, Almotriptan) -> Agonist des 5-HT₁-Rezeptors -> Vasokonstriktion
- Metoclopramid / Domperidon -> Übelkeit

Prophylaxe
- Betablocker (Metoprolol , Bisoprolol)
- Topiramat (Antikonsulsivum)
- Flunarizin (Ca-Antagonist)
Benigner paroxysmaler Lagerungsschwindel (#R: 0; #F: 1)
Kanalolithiasis/Cupulolithiasi
- Lösen von Otolithen

Plötzliche, rezidivierende Attacken für wenige Sekunden
- etwa 30-45sek.
- lagerungsabhängig
- Drehschwindel zur kranken Seite
- Nystagmus zur kranken Seite
- Fallneigung zur gesunden Seite
- Übelkeit
- KEINE Hörminderung; KEIN Tinnitus

Diagnostik
- Hallpike-Manöver

Therapie
- Befreiungsmanöver nach Epley (80-100% Erfolgsrate)
Propranolol (#R: -1; #F: 1)
= Unselektive Betablocker

- Hepatische Elimination
- Wirkdauer 12 Stunden

Indikation
-> Thyreotoxische Krise
-> Akute Aufregung und Unruhe
-> Portale Hypertension
C7-Syndrom (#R: 1; #F: 1)
Parese
- M. triceps brachii
- M. pronator teres
- Thenarmuskulatur

Dermatom
- Palmare Finger II - IV (halber Finger II, III ganz und halb von IV)
- Dorsaler, mittlerer Unterarm bis halber Finger II, III und halb von IV

Reflexminderung
- Trizepssehnenreflex (TSR)
L5-Syndrom (#R: 2; #F: 1)
Parese
- Fußhebung (M. extensor hallucis longus und M. extensor digitorum brevis)
- Hackengang geschwächt
- Großzehenheberschwäche

Dermatom
- Dorsolateraler Oberschenkel, Außenseite des Knies, ventraler Unterschenkel
- Fußrücken, Großzehe

Reflexminderung
- Tibialis-Posterior-Reflex (TPR)
Verapamil (#R: -1; #F: 1)
= Kalzium-Antagonisten vom Verapamil-Typ

- negative inotrop, dromotrop und chronotrop

Indikationen
- arteriellen Hypertonie
- stabile Angina pectoris
- Supraventrikuläre Tachykardie
- Raynaud-Syndroms (Nifedipin)

Nebenwirkungen
- Kopfschmerzen
- Flush
- periphere Ödeme
- reflektorische Tachykardien

Kontraindikationen
- Herzinsuffizienz
- Hypotension
- schwere stenosierende Herzvitien
- Kombination mit Nitraten
Blumberg-Zeichen (#R: -1; #F: 1)
Kontralateraler Loslasschmerz (im rechten Unterbauch) nach Palpation des linken Unterbauches
Bragard-Zeichen (#R: 1; #F: 1)
Bein wird im Kniegelenk gestreckt angehoben

Bei Dorsalextension des Fußes geäußerte Schmerzen sprechen ähnlich wie bei Lasègue-Zeichen für Nervendehnungsschmerz
Kartagener-Syndrom (#R: 1; #F: 1)
Autosomal-rezessiv vererbte Störung des mukozellulären Transports

Symptomtrias
- Situs inversus
- Bronchiektasen
- Chronische Sinusitis und Nasenpolypen
Nervus suprascapularis (#R: 1; #F: 1)
Motorik
- M. infraspinatus
- M. supraspinatus

Symptomatik
- Adduktion
- Abduktion
- Außenrotation
Frontobasale Frakturen (#R: 0; #F: 1)
Frakturen der vorderen Schädelbasis durch Gewalteinwirkungen von vorne
- Einteilung nach Escher

Leitsymptome:
- Monokel- oder Brillenhämatom
- subkonjunktivaler Einblutung (Hyposphagma).
- Bei Durazerreißung Rhinoliquorrhö
Kolonkarzinom - Lokal inoperable Tumoren - OP (#R: 2; #F: 0)
Zur Erhaltung der Passage bspw. Anlage eines endständigen Stomas oder Anlage eines Bypass als Umgehungsweg (z.B. Ileotransversostomie)
Gowers-Zeichen (#R: 2; #F: 0)
Das Gowers-Zeichen bezeichnet ein Phänomen bei der progressiven Muskeldystrophie Typ Duchenne: Um sich aufzurichten, stützt sich der Patient auf seinen Oberschenkeln ab. Er klettert gewissermaßen an sich hoch.
Pap 0 (#R: 0; #F: 0)
Abstrich unbrauchbar
Lingua geographica (#R: 1; #F: 0)
unregelmäßige rötliche und weiße Areale, die an das Bild einer Landkarte erinnern
Nervus fibularis communis-Läsion (#R: 1; #F: 0)
L4-S2

Ätiologie
- zu engen Gipsverband
- Fibulafraktur

Sensibilität
- Spatium interosseum 1 (Bereich zwischen erster und zweiter Zehe)
- lateraler Unterschenkel
- Fußrücken

Motorik
- Fuß- und Zehenheber (Steppergang)
- Gestörte Pronation
Tadalafil (#R: 0; #F: 0)
= Phosphodiesterase-V-Hemmer

Indikation
- Erektile Dysfunktion
- Pulmonale Hypertonie

Nebenwirkungen
- Kopfschmerzen und Schwindel
- Sehstörungen
- Flush
- Schnupfen
- Exanthem
CEA (#R: 0; #F: 0)
- Kolorektales Karzinom
- Bronchialkarzinome (insb. nicht-kleinzellige)
- Pankreaskarzinom
- Mammakarzinom
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Rektumkarzinom - Oberes und mittleres Drittel (bis 5cm ab ano) - OP (#R: 0; #F: 0)
Tiefe anteriore Rektumresektion (TAR) + totale mesorektale Exzision (TME)

Kontinenzerhaltend
Morbus Dupuytren (#R: 2; #F: 0)
Idiopathische Proliferation der Palmaraponeurose mit zunehmender Beugekontraktur insbesondere des kleinen Fingers
Pap I (#R: 0; #F: 0)
Physiologisches Zellbild

Routinekontrolle nach 12 Monaten
Glossitis rhombica mediana (#R: 1; #F: 0)
Ovale schmerzlose Rötung im mittleren Drittel der Zunge ventral des Foramen caecum
Nervus saphenus-Läsion (#R: 1; #F: 0)
Rein sensibler Ast des N. femoralis

Sensibilität
- infrapatellare Region
- medialer Unterschenkel
- medialer Fußrand
Vardenafil (#R: 0; #F: 0)
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Patellaspitzensyndrom (#R: 2; #F: 0)
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Leberzirrhose
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Hemmung der Natrium/Kalium-ATPase in den Kardiomyozyten
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- negativ dromotrop
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Indikationen
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- Herzinsuffizienz Stadium ≥ NYHA III
- Paroxysmale supraventrikuläre Tachykardie

Nebenwirkungen
- Gastrointestinale Nebenwirkungen
- Herzrhythmusstörungen
- Neurotoxizität: Sehstörungen
- Bei Digoxin: Niereninsuffizienz

Kontraindikationen
- Hypokaliämie
- Hyperkalzämie
- AV-Block ≥ II°
- Sick-Sinus-Syndrom
- Wolff-Parkinson-White-Syndrom
- Hypertrophische Obstruktive Kardiomyopathie (HOCM)
- Digoxin bei Niereninsuffizienz

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Proximale Schädigung
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Distale Schädigungen (im Bereich des Handgelenks)
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Klinische Zeichen
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Hemmung der Natrium/Kalium-ATPase in den Kardiomyozyten
- positiv inotrop
- negativ dromotrop
- geringe therapeutische Breite

Indikationen
- Tachykardes Vorhofflimmern
- Herzinsuffizienz Stadium ≥ NYHA III
- Paroxysmale supraventrikuläre Tachykardie

Nebenwirkungen
- Gastrointestinale Nebenwirkungen
- Herzrhythmusstörungen
- Neurotoxizität: Sehstörungen
- Bei Digoxin: Niereninsuffizienz

Kontraindikationen
- Hypokaliämie
- Hyperkalzämie
- AV-Block ≥ II°
- Sick-Sinus-Syndrom
- Wolff-Parkinson-White-Syndrom
- Hypertrophische Obstruktive Kardiomyopathie (HOCM)
- Digoxin bei Niereninsuffizienz

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Bennett-Fraktur (#R: 0; #F: 0)
Bei der Bennett-Luxationsfraktur besteht eine Dislokation im Daumensattelgelenk.
Morbus Scheuermann (#R: 2; #F: 0)
Aseptische Knochennekrose

- Deck-/Grundplatte der Wirbelkörper
- 11-13 Jahre
- Verstärkte Kyphosierung in der Brustwirbelsäule
- Hyperlordosierung in der Lendenwirbelsäule
- Radiologisch Schmorl-Knötchen
Doxorubicin (#R: 1; #F: 0)
= Topoisomerase-Hemmstoff
- Anthracyclin
- Interkalanz

Indikation
- Akute Leukämien
- Ovarialkarzinom

Nebenwirkung
- Kardiotoxizität
Pharynxkarzinom (#R: 2; #F: 0)
- meistens Plattenepithelkarzinom

Risikofaktoren
- Tabakkonsum
- Alkoholabusus
- Beim Nasopharynxkarzinom: EBV
- Beim Oropharynxkarzinom: HPV

- gehäuft Zweitkarzinome synchron oder metachron

Therapie
- Operation, Radiatio und/oder Chemotherapie

Prognose:
- schlecht
Amyotrophe Lateralsklerose (#R: 2; #F: 0)
Degenerative Erkrankung des 1. und des 2. Motoneurons
-> Zeitgleiches Auftreten spastischer (1. Motoneuron) UND schlaffer Paresen (2. Motoneuron = Vorderhornzelle)

- Altersgipfel > 70 Jahre

- Sensibilität NICHT betroffen
- Blasen- und Mastdarmfunktion NICHT betroffen

Frühsymptome
- atrophische, schlaffe Paresen (Hand-, Schulter-, Wadenmuskeln)
- Faszikulationen

Spätsymptome
- spastischer Paresen (Vorderhornzellen)
- bulbären Symptomatik (Hirnnervenkerne)
-> Dysarthrie, Dysphagie und Sialorrhoe
-> Atrophie der Zungenmuskulatur
-> Pathologisches Lachen und Weinen

- Erhöhung der Kreatinkinase (CK) im Serum

Elektromyelographie (EMG)
- Pathologische Spontanaktivität
- großamplitudiges, aber gelichtetes Aktivitätsmuster

Therapie
- Riluzol (Glutamat-Antagonist)
- Baclofen (gegen Spastik)
- Atropin (Gegen Hypersalivation)
- Opiate und Benzodiazepine

Prognose
- Versterben meist nach 3-5 Jahre an Ateminsuffizienz / Pneumonie
Neurofilamente (#R: 0; #F: 0)
- Neuroendokrine Tumoren
- Medulloblastom
- Kleinzelliges Bronchialkarzinom
- Merkelzell-Karzinom
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Work in Congress was interrupted on Thursday afternoon when the U.S. Capitol was locked down briefly due to gunshots fired outside the building. One female suspect was shot dead after a brief car chase across downtown Washington. Police said it appeared to be an isolated incident.
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Kahnbeinfraktur (#R: 0; #F: 0)
Der Druckschmerz distal des Processus styloideus radii in der sogenannten Tabatière (Foveola radialis) ist typisch für die Kahnbeinfraktur. Der Unfallhergang mit Sturz auf die ausgestreckten Hände ist klassisch.
Morbus Perthes-Legg-Calvé (#R: 2; #F: 0)
Aseptische Knochennekrose

- Femurkopf
- 4-8 Jahre
Cyclophosphamid (#R: 1; #F: 0)
= Alkylanz

Indikation
- Leukämien
- Multiples Myelom

Nebenwirkung
- Hämorrhagische Zystitis: Prophylaktische Gabe von Mesna
- Myelosuppression
Mundbodenkarzinom (#R: 1; #F: 0)
- meist Plattenepithelkarzinom

Risikofaktoren
- Nikotinabusus
- Alkoholabusus
- Schlechte Mundhygiene, mechanische Störungen (schlecht sitzende Zahnprothesen)
- HPV 16, 18, 31 und 33 (ca. 30%)

- Ulzerös (wächst endophytisch nach innen)
- Verrukös (wächst exophytisch nach außen)
Progressive Bulbärparalyse (#R: 1; #F: 0)
Degeneration der motorischen Hirnnervenkerne im Bulbus der Medulla oblongata

- Bei amyotrophen Lateralsklerose oder Poliomyelitis

- Dysarthrie (sog. bulbäre Sprache)
- Dysphagie
- Pathologisches Lachen und Weinen
- Amimie
- Atrophische Zungenparese
- Fibrillationen
Tirofiban (#R: 0; #F: 0)
= Thrombozytenaggregationshemmer
= Glykoprotein-IIb/IIIa-Antagonisten
Prävention von arteriellen Embolien

Indikation
- PTCA mit hohem Risiko
- Instabile Angina pectoris

Nebenwirkungen
- Blutungen
CD20 (#R: 0; #F: 0)
B-Zell-Lymphome
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Pleased to meet you http://silverdaddies.fun/ silverdaddies Smith said Bernhard told players he has their “best intentions at heart and that he would ensure we had updated facilities, but we had to agree to being back practicing Monday ... and finish the remainder of our season.” (#R: 0; #F: 0)
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Chilaiditi-Syndroms (#R: 9; #F: 0)
Verlagerung der Flexura coli dextra nach kranial zwischen Zwerchfell und Leber.

- nicht zwingend Krankheitswert
- häufig als Zufallsbefund
- erhöhte Gefahr eines Darmverschlusses
Thompson-Test (#R: 2; #F: 0)
Bei Spieler B spricht der peitschenartige Knall mit der Folge eines dumpfen Schmerzes nach längerer Belastung für eine Achillessehnenruptur. Der Thompson-Test ist eine geeignete Untersuchungsmethode, um diese Diagnose zu festigen. Bei rupturierter Achillessehne wäre die passive Plantarflexion des Fußes bei Wadenkompression ausgefallen, und der Thompson-Test somit positiv.
Morbus Sever-Haglund (#R: 2; #F: 0)
Aseptische Knochennekrose

- Apophysis calcanei / Fersenbeinapophyse
- 5-12 Jahre
Urethrozystometrie (#R: 1; #F: 0)
Urodynamik
- Messung der Harnblasendrücke während des Miktionsvorgangs
- Messung über einen transurethralen und rektalen Druckmesskatheter sowie über ein EMG der Beckenbodenmuskulatur

- Unterscheidung von subvesikaler Obstruktion und neurogenen Harnblasenentleerungsstörungen
- Bestimmung des Harnröhrenverschlussdrucks bei Inkontinenz
Parese des N. laryngeus superior (#R: 1; #F: 0)
- Lähmung des M. cricothyroideus (Externus)

- Schlaffe Stimmlippe auf der betroffenen Seite
- Stimmlippen sind normal beweglich
- Dysphonie mit Störung der hohen Töne beim Sprechen
Spinale Muskelatrophien (#R: 1; #F: 0)
Nicht-entzündliche Degeneration des 2. Motoneurons

Ätiologie
- hereditär -> im Kindesalter
- sporadisch -> im Erwachsenenalter

- atrophischen Paresen
- Areflexie
- Faszikulationen

Elektromyographie (EMG)
- pathologische Spontanaktivität
- Riesenpotentiale

Muskelbiopsie
- Faseratrophie
- Hypertrophie der verbliebenen Fasern
Unfraktioniertes Heparin (#R: 0; #F: 0)
= Nicht-orale Antikoagulation
Hemmung der plasmatischen Blutgerinnung
-> Vermeidung und Behandlung von Thrombosen

- Subkutan / Intravenös
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Indikationen
- Thromboseprophylaxe
- Vorhofflimmern
- Thrombose, Lungenembolie
- Akutes Koronarsyndrom
- Mechanischer Klappenersatz
- Prophylaxe der Thrombenbildung bei Hämodialyse, Herz-Lungen-Maschine u.a.

Nebenwirkungen
- HIT I (5 Tage)
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- Vorhofflimmern
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Psammomkörperchen (#R: 0; #F: 0)
Verkalkung mit lamellärer konzentrischer Schichtung

Auftreten beim papillären Schilddrüsenkarzinom (Nachweis im Schilddrüsengewebe ist immer malignomsuspekt),
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Collum-Centrum-Diaphysen-Winkel (#R: 2; #F: 0)
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Symptome
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Nebenwirkungen
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Lewy-Körperchen (#R: 2; #F: 0)
Beim Morbus Parkinson sowie bei der gleichnamigen Lewy-Body-Demenz kommt es zur Ablagerung hyaliner, eosinophiler Einschlusskörperchen in untergegangenen neuronalen Zellen.
Antetorsionswinkel (#R: 2; #F: 0)
Winkel, der von der Hauptachse des Oberschenkelhalses und der Querachse der beiden Oberschenkelkondylen des distalen Oberschenkels gebildet wird

- Physiologisch ca 12°
Ureter fissus (#R: 1; #F: 0)
- Zwei Harnleiter
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- ein Harnleiterostium

Möglicher Jo-Jo-Effekt des Urins bei Y-förmigem Harnleiter (uretero-uretraler Reflux)
Stimmlippenpolyp (#R: 1; #F: 0)
Häufigste gutartige Stimmbandänderung
- Heiserkeit

- Oft am Übergang von vorderem zum mittlerem Stimmbanddrittel
- Therapie: Endoskopische Abtragung
Myasthenia gravis (#R: 1; #F: 0)
Störung der Signalübertragung an der motorischen Endplatte
- in der Synapse zwischen Neuron und Muskel
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- Häufig assoziiert mit Thymusveränderungen (Thymom, ...)

- Einteilung nach Ossermann (Stadium I [okulär] - IV [chronisch-schwer])

Symptome
Unnatürlichen Ermüdbarkeit besonders empfindlicher Muskeln
-> gegen Abend und in bestimmten Stresssituationen zunehmend
- Ptosis
- Diplopie
- Dysarthrie
- Dysphagie
- schlaffe Gesichtszüge (sog. Facies myopathica)
- Wechselnde Augenmuskelparesen

Diagnostik
- Simpson-Test (Ptosis bei Aufwärtsblick)
- Tensilon-Test (Besserung auf kurzwirksame Acetylcholinesterase-Hemmer)
- Eis-Test (Besserung bei Kälte)
- Elektromyogramm (Dekrement)

Therapie
1) Acetylcholinesterase-Hemmer
- Pyridostigmin
2) Immunsuppressiva
- Glukokortikoide
- Azathioprin
- Plasmapherese/Immunglobuline)
3) Thymektomie
- häufig Symptomrückgang, selten Heilung
Fondaparinux (#R: 0; #F: 0)
= Nicht-orale Antikoagulation4
= Synthetisches Heparin
Hemmung der plasmatischen Blutgerinnung
-> Vermeidung und Behandlung von Thrombosen

- Subkutan
- Monitoring: Anti-FXa-Aktivität

Indikationen
- Thromboseprophylaxe
- Vorhofflimmern
- Thrombose, Lungenembolie
- Akutes Koronarsyndrom
- Mechanischer Klappenersatz
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- gesetzlichen Krankenversicherung (GKV)
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-> Pflichtversicherungen
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Hemmung der plasmatischen Blutgerinnung
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- Subkutan
- Monitoring: Anti-FXa-Aktivität

Indikationen
- Thromboseprophylaxe
- Vorhofflimmern
- Thrombose, Lungenembolie
- Akutes Koronarsyndrom
- Mechanischer Klappenersatz
- Prophylaxe der Thrombenbildung bei Hämodialyse, Herz-Lungen-Maschine u.a.

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Zystische Umwandlung umschriebener Nephronabschnitte (Mark und Rinde) beidseits!

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Formen
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Sekundäre Gonarthrose - Ursachen (#R: 2; #F: 0)
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Symptome
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Klinische Zeichen
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Diagnostik
1) Kreatinkinase im Serum↑↑
2) Elektromyogramm
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Interaktionen (Marcumar)
1) Wirkungsverstärkung
1.1 Hemmung des metabolischen Abbaus (Cytochrom P-450)
- Allopurinol
- Paracetamol
1.2 Verdrängung aus der Plasma-Eiweiß-Bindung
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2) paraneoplastisch im Rahmen eines Bronchial- oder Mamma-Ca
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- gleichzeitige Agonisten- und Antagonistenaktivität
2) Liquor
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- autochthone IgG-Vermehrung
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Extremvariante: "Upside-down-stomach" (Magenvolvulus)
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Idiopathische primär fokale zervikale Dystonie
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Symptome
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Unterdrückung durch den Patienten mittels Geste antagonistique
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Kompetitive Hemmung der HMG-CoA-Reduktase
- Abendliche Einnahme (v.a. bei Simvastatin)
- Kombinationstherapie mit Colestyramin

Vertreter
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- CYP3A4
2) Pravastatin
- HWZ: 2h
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3) Lovastatin
- HWZ: 3h
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4) Atorvastatin
- HWZ: 14h
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Indikation
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Nebenwirkungen
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Erhöhte Myopathie- und Rhabdomyolyseneigung bei:
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Kontraindikationen
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- Muskelerkrankungen
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Entschädigung von
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Epitheleinschlüsse in zervikalen Lymphknoten

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Aktivierung des PPARα-Rezeptors
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Vertreter
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Indikation
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Nebenwirkungen
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die Auswirkungen der einzelnen Funktionsbeeinträchtigungen in ihrer Gesamtheit unter Berücksichtigung ihrer wechselseitigen Beziehungen zueinander gewertet

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Austauscherharz (Bindung der Gallensäure im Darm)
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Indikation
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- Gastrektomie: diffuser Typ
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Vertreter
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Desault-Verband (#R: 2; #F: 0)
Nach Reposition einer Schultereckgelenkluxation kann das Gelenk durch ein Desault- oder Gilchristverband ruhiggestellt werden.
Chorionkarzinom oder Keimzelltumoren - Tumormarker (#R: 0; #F: 0)
HCG
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Pus zwischen der Niere und Gerota-Faszie

Therapie
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Nervus oculomotorius (III), trochlearis (IV), abducens (VI)

Augenbewegungen
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Nahakkommodation
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Lidhebung (M. levator palpebrae)
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Protonenpumpenhemmer (#R: 0; #F: 0)
Irreversible Hemmung der H+/K+-ATPase der Parietalzellen
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Indikationen
- Ulcus ventriculi und duodeni
- Refluxkrankheit
- Eradikation von Helicobacter pylori
- Zollinger-Ellison-Syndrom
- Gastropathien durch NSAR

Nebenwirkungen
- Gastrointestinale Nebenwirkungen (10%)
- Schwindel, Kopfschmerzen
- Sehstörungen (bei iv. Applikation)
- Exantheme
- Reaktive Hypergastrinämie
Metalldampffieber (#R: 3; #F: 0)
- Akute Beschwerden durch Inhalation von metallhaltigen Aerosolen (v.a. Kupfer und Zink)
- Grippeartige Symptome
- Folgenloses Abklingen
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Dachziegel-Verband (#R: 1; #F: 0)
Zehenfrakturen werden (evtl. nach Reposition) durch einen Pflasterzügelverband (Dachziegel-Verband) versorgt, indem durch dachziegelartig überlappende Anordnung von Tape-Verbänden der frakturierte Zeh durch den benachbarten gesunden Zeh geschient wird.
vaginale Leukoplakie (#R: 1; #F: 0)
Bei Leukoplakien handelt es sich um weißliche nicht abwischbare Beläge, die aufgrund von Zellatypien entstehen. Sie sind nicht zwingend pathologisch, da sie auch einfache Hyperkeratosen sein können. Da sich aber auch zervikale intraepitheliale Neoplasien (CIN) als Leukoplakien darstellen können und eine makroskopische Differenzierung schwierig ist, sollte stets eine weitere Abklärung mit Hilfe einer Biopsie erfolgen.
Paranephritischer Abszess (#R: 1; #F: 0)
Durchbruch der Gerota-Faszie mit Eiterentleerung ins Retroperitoneum
N. V (#R: 3; #F: 0)
Nervus trigeminus

Sensibilität
- Bestreichen der drei unterschiedlichen Gesichtsregionen

Kaumuskulatur (M. temporalis, M. masseter)
- Mund öffnen und schließen lassen, gleichzeitige Palpation der Masseteren

Masseterreflex
Nervenaustrittspunkte

Kornealreflex
- Wattebausch vom Lidrand an die Kornea annähern
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- Selbstüberschätzung
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Antidiabetika (#R: 0; #F: 0)
Vertreter
1) Biguanide
- Metformin

2) Sulfonylharnstoffe
- Glibenclamid
- Glimepirid

3) Glinide
- Repaglinid

4) α-Glukosidasehemmer
- Acarbose

5) Glitazone
- Pioglitazon
- Rosiglitazon

6) Inkretinmimetika
- Exenatide

7) Dipeptidylpetidase-4-Hemmer
- Sitagliptin
- Vildagliptin
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Kirchmayr-Kessler-Naht (#R: 0; #F: 0)
Die Kirchmayr-Kessler-Naht beschreibt eine End-zu-End Durchflechtungsnaht zur Versorgung einer rupturierten Sehne. Sie wird grundsätzlich bei Beugesehnenverletzungen der Hand oder auch bei der Achillessehnenruptur angewendet.
Portioektopie (#R: 0; #F: 0)
Die Portioektopie beschreibt das Vorhandensein von endometrialem Zylinderepithel der Endozervix auf der vaginalen Portiooberfläche, was einen physiologischen Zustand unter Östrogen- und Gestageneinfluss darstellt. In der Kolposkopie stellt sie sich als gleichmäßige papilläre Struktur dar.

Eine Portioektopie kann, aufgrund der im Vergleich zum Plattenepithel der Scheide geringeren Resistenz, beim Geschlechtsverkehr Kontaktblutungen verursachen. Bei HPV-16,18-Befall neigt das ektope Gewebe bevorzugt dazu maligne zu entarten.
4-Gläser-Probe (#R: 1; #F: 0)
1. Portion (Anfangsurin, erste 10-20ml)
- Urethra

2. Portion (Mittelstrahlurin)
- Blase, obere Harnwege

3. Portion (Prostataexprimat, während Prostatamassage)
- Prostata

4. Portion (Exprimaturin, nach Prostatamassage)
- Prostata
N. VII (#R: 2; #F: 0)
Nervus facialis

Mimische Muskulatur
- Stirnrunzeln, nach oben sehen lassen, Augen zukneifen, Nase rümpfen, Wangen aufblasen, Zähne zeigen, Pfeifen

Geschmackstestung
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Nervenäste:
1) N. petrosus major
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2) N. stapedius
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3) Chorda tympani
- Geschmacksfasern
- Glandula sublingualis und Glandula submandibularis
Emotional instabile Persönlichkeit (#R: 1; #F: 0)
Persönlichkeitsstörung
- Beginn meist in der Adoleszenz (Altersgipfel: 25 Jahre)

Einteilung
1) implusiver Typus (Konfliktbereitschaft)
2) Borderline-Typus (psychotisch: z.B. Wahn; neurotisch: z.B. Affektstörungen+ Ängste)

Symptome (Beide Typen)
- mangelnde Impulskontrolle
- unüberlegtes Handeln ohne Berücksichtigung der Konsequenzen
- verstärkte Konfliktbereitschaft
- Störung des Selbstbildes

Borderline-Typ
- Traumatische Ereignisse in der Kindheit
- Störungen bezüglich der eigenen Identität und Ziele
- unbeständige Beziehungen
- chronisches Gefühl von Leere
- selbstzugefügten Verletzungen (Ritzen)
- suizidale Handlungen

Therapie
- Psychotherapiekonzepten (dialektisch-behaviorale Therapie nach Linehan)
- Antidepressiva (SSRI)
- Antipsychotika
- KEINE Benzos
Biguanide (#R: 0; #F: 0)
- Vaskuläre Komplikationen↓
- Mortalität durch mikro- und makroangiopathische Folgeerkrankungen↓
- Keine erhöhte Hypoglykämiegefahr

Vertreter
- Metformin

BZ bis zu 40%↓
- Insulinwirkung↑
- Kohlenhydratumsatz↑
- Glukoneogenese↓
- Resorption Kohlenhydrate im Darm↓

- Lipolyse↑
- Triglycerid- und LDL-Spiegel↓

Nebenwirkungen
- Gastrointestinale Nebenwirkungen
- Laktatazidose

Kontraindikationen
- Niereninsuffizienz (Kreatinin >1,2mg/dL, GFR
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Lesch-Nyhan-Syndrom (#R: 5; #F: 0)
Überproduktion von Harnsäure
Paget-von-Schroetter-Syndrom (#R: 2; #F: 0)
tiefe Armvenenthrombose

Ätiologie
- extremer Belastung (Tennis) des Arms
- Fremdkörper (ZVK)
Östrogen (#R: 1; #F: 0)
- Steroidhormon (Estradiol, Estron, Estriol)
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- - LH: Stimulation der Androgensynthese in den Thekazellen des Ovars
- - FSH: Stimulation der Umwandlung dieser Androgene in Östrogene
- - Enzym: Aromatase
N. VIII (#R: 2; #F: 0)
Nervus vestibulocochlearis

Prüfung des Hörsinns
- Reiben der Finger vor dem Meatus acusticus externus (Gehörgang)

Orientierende Unterscheidung zwischen Schallempfindungs- und Schallleitungsschwerhörigkeit durch Rinne- und Weber-Versuch
Dialektisch-behavioralen Therapie (#R: 1; #F: 0)
Zur Therapie der motional-instabilen Persönlichkeitsstörungen vom Borderline-Typ

- Innere Achtsamkeit
- Bewusster Umgang mit Gefühlen
- Selbstwert
- Stresstoleranz
- Zwischenmenschliche Fähigkeiten
Sulfonylharnstoffe (#R: 0; #F: 0)
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- Keine erhöhte Hypoglykämiegefahr

Vertreter
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Nebenwirkungen
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Kontraindikationen
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- Gleichzeitige Gabe mit Kontrastmittel i.v.
- OP

Wechselwirkungen:
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Maisonneuve-Fraktur (#R: 2; #F: 0)
Eine Abrissfraktur des Innenknöchels mit gleichzeitiger subkapitaler Fibulafraktur und Längsriss der Membrana interossea stellt eine hohe (subkapitale) Weber-C-Fraktur dar, die auch als Maisonneuve-Fraktur bezeichnet wird.
Östrogen - Nebenwirkungen (#R: 0; #F: 0)
- Erhöhte Thromboseneigung!
- Depressive Verstimmung
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- Mammakarzinom↑
- Kolorektales Karzinom↓
Prehn-Zeichen (#R: 1; #F: 0)
Schmerznachlass bei Anheben des Skortums
- Bei Epididymitis
N. IX (#R: 2; #F: 0)
Nervus glossopharyngeus
- tritt kranial des N. vagus seitlich aus der Medulla oblongata aus

Inspektion der Uvula und Gaumensegel
- Bei Störung der Innervation Abweichung des Gaumensegels zur gesunden Seite (Kulissenphänomen)

Würgereflex
- Holzspatel/langen Wattebausch kurz und vorsichtig Richtung Uvula führen
- Würgereflex eingeschränkt bei Ausfall des Nerven

Geschmackstestung
- Hinteres Drittel der Zunge ipsilateral (bitter)

- sensorisch für Ohrenschmerzen verantwortlich
Borderline-Störung (#R: 1; #F: 0)
Emotional instabile Persönlichkeitsstörung
- Störung zwischen den ehemals neurotischen (z.B. Konversions-, Angst-, Zwangsstörungen) und den psychotischen Störungen (z.B. Schizophrenie)

1) Impulskontrollstörung
- Hochrisikoverhalten
- Fressanfällen
- Abbrüchen der beruflichen Ausbildung / privater Beziehungen / Therapie

2) Selbstverletzendes Verhalten
- Ritzen / Zigarettenausdrücken
- führt suchtähnlich zu euphorisierenden Kicks

3) Suizidalität
4) Derealisation
5) Agieren
6) Gesteigerte Affekte
7) Polytoxikomanie
8) Polymorph-perverse Sexualität
Sulfonylharnstoffe (#R: 0; #F: 0)
Verschluss von Kaliumkanälen der ß-Zellen des Pankreas → Insulinsekretion↑
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Vertreter
- Glibenclamid
- Glimepirid

- Gewichtszunahme

Nebenwirkungen
- Lebensgefährliche Hypoglykämien

Kontraindikationen
- Leber- und Niereninsuffizienz
- Sulfonamidallergie
- Schwangerschaft und Stillzeit
- Operation

Wechselwirkungen:
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Chrom (#R: 3; #F: 0)
Ätzend, allergen

Klinik
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- Ulzeration der Nasenscheidewand durch kontaminierte Fingerberührung
- Hartmetalllunge
- Bronchialkarzinom

Diagnostik
- Nachweis im Urin oder Blut
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Die Weber-A-Fraktur ist eine Fraktur des Außenknöchels unterhalb der intakt gebliebenen Syndesmose.
1. Zyklushälfte (Tag 1-14) (#R: 1; #F: 0)
Leithormone:
- Östrogen
- FSH in der Frühphase
- LH als Ovulationsreiz

Ovar:
- Follikelphase (Heranreifen von Follikel unter FSH) -> produzieren Östrogen -> LH-Freisetzung

Endometrium:
- Desquamationsphase (Tag 1-4): Abstoßung der Lamina functionalis.
- Proliferationsphase (Tag 4-15): Proliferation des Endometriumepithels
Hydrozele testis (#R: 1; #F: 0)
Schmerzlose Wassersackbildung zwischen den Hodenhüllen im Skrotum
N. X (#R: 2; #F: 0)
Nervus vagus
Kehlkopfmuskeln, die Atem- und obere Speisewegsmuskulatur, Gaumensegel

- Heiserkeit (N. laryngeus recurrens)
- Schluckbeschwerden
- Abweichung der Rachenhinterwand zur gesunden Seite (Kulissenphänomen)
- Epiglottisparese
- Glottisparese

Würgereflex
- Holzspatel/langen Wattebausch kurz und vorsichtig Richtung Uvula führen
- Würgereflex eingeschränkt bei Ausfall des Nerven
Autismus (#R: 1; #F: 0)
Tief greifende Entwicklungsstörung
- Abweichungen in sozialen Interaktionen
- Abweichungen in der Kommunikation
- eingeschränkte, stereotype Interessen und Aktivitäten

Ätiologie - multifaktoriell
- Genetik: Entscheidender Faktor in der Pathogenese

Klassifikation
- Frühkindlicher Autismus
- Atypischer Autismus
- Rett-Syndrom
- Andere desintegrative Störung des Kindesalters (z.B. Hellersche Demenz)
- Asperger-Syndrom
Glinide (#R: 0; #F: 0)
Verschluss von Kaliumkanälen der ß-Zellen des Pankreas → Insulinsekretion↑
- Einnahme vor dem Essen

Vertreter
- Repaglinid

Nebenwirkungen
- Lebensgefährliche Hypoglykämien
- Gewichtszunahme

Kontraindikationen
- Leber- und Niereninsuffizienz
- Sulfonamidallergie
- Schwangerschaft und Stillzeit
- Operation

Wechselwirkungen:
- Sulfonylharnstoffe: Glibenclamid
Quecksilber (#R: 3; #F: 0)
Klinik
- Blauviolette Verfärbung des Zahnfleischrandes
- Gastroenteritis (blutige Diarrhö)
- Nierenversagen
- Entzündungen der Atemwege
- Glomeruläre Nierenschädigung (Albuminurie)
- ZNS-Störungen (Erethismus und Tremor mercurialis)
- Polyneuropathie

Diagnostik
- Anorganisches Quecksilber im Urin
- Organisches Quecksilber im Blut

Sonstiges
- Minamata-Krankheit (Tausende Erkrante durch Fisch-Verzehr und teratogenen Wikrungen)

Therapie
- D-Penicillamin
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Weber-B-Fraktur (#R: 1; #F: 0)
Die Weber-B-Fraktur ist eine Fraktur des Außenknöchels in Höhe der dann meist teilruptierten Syndesmose.
2. Zyklushälfte (Tag 14-28) (#R: 0; #F: 0)
Leithormone:
- Progesteron
- LH

Ovar:
- Lutealphase: Graafscher Follikel -> Corpus luteum -> Progesteron

Endometrium:
- Sekretionsphase: Differenzierung des Endometriums
N. XI (#R: 2; #F: 0)
Nervus accessorius

M. trapezius
- Schulterheben gegen Widerstand

M. sternocleidomastoideus
- Kopfdrehen gegen Widerstand
Hellersche Demenz (#R: 1; #F: 0)
= infantile Demenz = desintegrative Psychose
Autismus-Unterform

- Phase der normalen Entwicklung
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- autistisches Verhalten
- Stereotypen
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α-Glukosidasehemmer (#R: 0; #F: 0)
Glukoseresorption in Intestinum↓
- Einnahme vor dem Essen

Vertreter
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Nebenwirkungen
- Gastrointestinale Nebenwirkungen (starke Blähungen möglich!)
- Gewichtsreduktion möglich

Kontraindikationen
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Prognose
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ca. 10-20% der Konkremente

Magnesiumammoniumphosphatsteine
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Prognose
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